Magnetic resonance findings of the corpus callosum in canine and feline lysosomal storage diseases.

[gm1 gangliosidosis]

Several reports have described magnetic resonance (MR ) findings in canine and feline lysosomal storage diseases such as gangliosidoses and neuronal ceroid lipofuscinosis . Although most of those studies described the signal intensities of white matter in the cerebrum , findings of the corpus callosum were not described in detail . A retrospective study was conducted on MR findings of the corpus callosum as well as the rostral commissure and the fornix in 18 cases of canine and feline lysosomal storage diseases . This included 6 Shiba Inu dogs and 2 domestic shorthair cats with GM 1 gangliosidosis ; 2 domestic shorthair cats , 2 familial toy poodles , and a golden retriever with GM 2 gangliosidosis ; and 2 border collies and 3 chihuahuas with neuronal ceroid lipofuscinoses , to determine whether changes of the corpus callosum is an imaging indicator of those diseases . The corpus callosum and the rostral commissure were difficult to recognize in all cases of juvenile -onset gangliosidoses (GM 1 gangliosidosis in Shiba Inu dogs and domestic shorthair cats and GM 2 gangliosidosis in domestic shorthair cats ) and GM 2 gangliosidosis in toy poodles with late juvenile -onset . In contrast , the corpus callosum and the rostral commissure were confirmed in cases of GM 2 gangliosidosis in a golden retriever and canine neuronal ceroid lipofuscinoses with late juvenile - to early adult-onset , but were extremely thin . Abnormal findings of the corpus callosum on midline sagittal images may be a useful imaging indicator for suspecting lysosomal storage diseases , especially hypoplasia (underdevelopment ) of the corpus callosum in juvenile -onset gangliosidoses .

Diseases
Validation

Diseases presenting "neuronal ceroid lipofuscinoses" symptom

gm1 gangliosidosis

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