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Focal myositis: a clinicopathological study.
[focal myositis]
Focal
myositis
is
a
rare
,
benign
inflammatory
condition
that
may
clinically
simulate
a
soft
tissue
sarcoma
.
It
was
first
described
in
1977
and
around
30
cases
have
been
reported
to
date
.
We
report
two
further
cases
on
which
we
have
performed
immunocytochemistry
and
electron
microscopy
.
Histology
of
both
lesions
was
identical
,
showing
a
destructive
inflammatory
myopathy
with
evidence
of
regeneration
.
Stains
for
micro-organisms
were
negative
and
no
viral
particles
were
seen
on
electron
microscopy
.
The
immunocytochemical
profile
of
our
two
cases
differed
from
that
of
polymyositis
:
with
a
panel
of
T
-
and
B-
cell
markers
the
cellular
infiltrate
was
found
to
be
composed
of
T
-
lymphocytes
and
variable
numbers
of
macrophages
:
sub-typing
in
one
case
revealed
the
T
-
cells
to
be
predominantly
CD
4
+
cells
.
Use
of
antibodies
to
MHC
class
1
and
2
antigens
showed
occasional
positive
inflammatory
cells
only
.
Clinicopathological
correlations
and
the
differential
diagnosis
are
discussed
.