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Clinical and pathologic features of focal myositis.
[focal myositis]
To
clarify
the
nosology
of
focal
myositis
(
FM
)
,
we
report
the
clinical
and
pathologic
features
of
eight
patients
presenting
with
focal
enlargement
of
one
muscle
.
Most
patients
improved
without
immunosuppressive
therapy
,
and
none
developed
polymyositis
.
Pathologic
features
were
those
of
an
inflammatory
myopathy
,
with
muscle
fiber
hypertrophy
and
moderate
to
severe
inflammation
.
In
most
cases
,
a
clustering
of
tightly
packed
muscle
fibers
,
enveloped
by
a
thick
bundle
of
fibrosis
,
was
associated
with
the
diagnosis
of
FM
.
Immunohistochemistry
showed
T
cell
predominance
within
the
interstitial
infiltrates
in
all
cases
.
No
evidence
of
vasculitis
was
present
.
Our
findings
suggest
that
FM
is
a
benign
condition
that
has
certain
clinical
features
separating
it
from
other
inflammatory
myopathies
.
Pathologic
changes
,
such
as
large
clusters
of
nesting
muscle
fibers
surrounded
by
thick
fibrosis
,
are
more
characteristic
of
FM
than
polymyositis
.
Diseases
Validation
Diseases presenting
"myositis"
symptom
focal myositis
inclusion body myositis
malignant atrophic papulosis
pyomyositis
systemic capillary leak syndrome
This symptom has already been validated
