Trypanosoma cruzi: mixture of two populations can modify virulence and tissue tropism in rat.

[focal myositis]

In rats , CL-Brener clone caused high mortality , severe acute myocarditis , and myositis that subsided completely in surviving animals . Accordingly , no parasite kDNA could be amplified in several organs after 4 months . The monoclonal JG strain caused null mortality , acute predominantly focal myocarditis , discrete and focal myositis , and a chronic phase with sparse inflammatory foci . Double infection with both Trypanosoma cruzi populations turned mortality very low or null . At the end of the acute phase , the heart exhibited only JG strain kDNA (LSSP-PCR ), while skeletal muscles and rectum exhibited only CL-Brener kDNA . Molecular and histopathological findings were accordant . In double infection chronic phase , JG strain remains in heart and appeared in organs previously parasitized by CL-Brener clone . Understanding the virulence and histotropism shifts now described could be important to clarify the variable clinical course and epidemiological peculiarities of Chagas ' disease .

Diseases
Validation

Diseases presenting "chronic phase" symptom

acute rheumatic fever

focal myositis

hydrocephalus with stenosis of the aqueduct of sylvius

systemic capillary leak syndrome

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