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HLA typing in focal myositis.
[focal myositis]
It
is
still
controversial
if
idiopathic
focal
myositis
is
a
part
of
systemic
polymyositis
.
We
present
here
four
patients
,
including
identical
twins
,
with
focal
myositis
accompanied
by
the
same
HLA
typings
.
Gradually
developing
unilateral
calf
muscle
pain
was
an
initial
symptom
in
all
patients
.
Neither
muscular
weakness
nor
creatine
kinase
(
CK
)
elevation
was
observed
,
while
minimal
inflammatory
findings
such
as
erythrocyte
sedimentation
rate
(
ESR
)
increase
appeared
in
serum
.
Magnetic
resonance
imaging
(
MRI
)
revealed
localized
abnormalities
of
calf
muscles
.
Biopsy
specimen
was
characterized
by
perimysial
and
endomysial
inflammatory
infiltration
consisted
of
T
cells
and
macrophages
and
rare
necrotic
fibers
.
Corticosteroid
administrations
ameliorated
their
symptoms
and
signs
,
though
recurrence
occurred
along
with
decreasing
doses
.
HLA
typings
common
to
all
patients
were
A
2
,
B
62
,
Cw
3
,
and
DQ
3
,
whereas
HLA-D
DNA
typings
were
DQB
1
*
0303
for
two
patients
,
and
DQB
1
*
0302
for
three
patients
.
These
findings
suggest
that
at
least
some
focal
myositis
may
be
a
new
disease
unit
,
with
a
common
genetic
background
but
not
a
part
of
systemic
polymyositis
.
Diseases
Validation
Diseases presenting
"minimal inflammatory findings"
symptom
focal myositis
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