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Specific matrix metalloproteinase expression in focal myositis: an immunopathological study.
[focal myositis]
The
aim
of
our
study
was
to
investigate
immunoexpression
of
matrix
metalloproteinases
MMP
2
,
MMP
7
and
MMP
9
in
muscle
specimens
from
patients
with
focal
myositis
(
FM
)
vs
polymyositis
(
PM
)
and
dermatomyositis
.
We
studied
muscle
biopsy
samples
from
seven
patients
affected
by
FM
;
samples
from
five
patients
each
with
PM
and
dermatomyositis
were
studied
as
disease
controls
.
MMP
2
immunoreactivity
was
present
in
PM
and
dermatomyositis
,
MMP
7
only
in
PM
,
and
MMP
9
in
PM
,
dermatomyositis
and
FM
.
O
ur
results
confirm
that
increased
MMP
9
immunoreactivity
in
muscle
fibres
is
a
common
feature
of
all
inflammatory
myopathies
and
suggest
that
MMP
2
and
MMP
7
can
not
be
implicated
in
the
inflammatory
events
of
FM
.
