Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Bilateral increase in expression and concentration of tachykinin in a unilateral rabbit muscle overuse model that leads to myositis.
[focal myositis]
Tachykinins
can
have
pro-
inflammatory
as
well
as
healing
effects
during
tissue
reorganization
and
inflammation
.
Recent
studies
report
an
up-regulation
in
the
expression
of
the
substance
P
(
SP
)
-
preferred
receptor
,
the
neurokinin-
1
receptor
,
in
marked
muscle
inflammation
(
myositis
)
.
There
is
,
however
,
only
very
little
information
on
the
expression
patterns
and
levels
of
tachykinins
in
this
situation
.
The
tachykinin
system
was
analyzed
using
a
rabbit
experimental
model
of
muscle
overuse
,
whereby
unilateral
muscle
exercise
in
combination
with
electrical
stimulation
led
to
muscle
derangement
and
myositis
in
the
triceps
surae
muscle
(
experimental
length
1
-
6
weeks
)
.
Evaluations
were
made
for
both
parts
of
the
muscle
(
soleus
and
gastrocnemius
muscles
)
in
experimental
and
non-experimental
(
contralateral
)
sides
.
Morphologic
evaluation
,
immunohistochemistry
,
in
situ
hybridization
and
enzyme
immunoassay
(
EIA
)
analyses
were
applied
.
Myositis
and
muscle
derangement
occurred
focally
not
only
in
the
experimental
side
but
also
in
the
non-experimental
side
.
In
the
inflammatory
areas
(
focal
myositis
areas
)
,
there
were
frequent
nerve
fibers
showing
tachykinin-like
immunoreactivity
and
which
were
parts
of
nerve
fascicles
and
which
were
freely
dispersed
in
the
tissue
.
Cells
in
the
inflammatory
infiltrates
showed
tachykinin-like
immunoreactivity
and
tachykinin
mRNA
expression
.
Specific
immunoreactivity
and
mRNA
expression
were
noted
in
blood
vessel
walls
of
both
sides
,
especially
in
focally
affected
areas
.
With
increasing
experimental
length
,
we
observed
an
increase
in
the
degree
of
immunoreactivity
in
the
vessel
walls
.
The
EIA
analyses
showed
that
the
concentration
of
tachykinin
in
the
tissue
on
both
sides
increased
in
a
time-dependent
manner
.
There
was
a
statistical
correlation
in
the
concentration
of
tachykinin
and
the
level
of
tachykinin
immunoreactivity
in
the
blood
vessel
walls
between
experimental
and
non-experimental
sides
.
T
he
observations
show
an
up-regulation
of
the
tachykinin
system
bilaterally
during
muscle
derangement
/
myositis
in
response
to
pronounced
unilateral
muscle
overuse
.
This
up-regulation
occurred
in
inflammatory
areas
and
was
related
not
only
to
increased
tachykinin
innervation
but
also
to
tachykinin
expression
in
blood
vessel
walls
and
inflammatory
cells
.
Importantly
,
the
tachykinin
system
appears
to
be
an
important
factor
not
only
ipsilaterally
but
also
contralaterally
in
these
processes
.
Diseases
Validation
Diseases presenting
"was related not only to increased tachykinin innervation but also to tachykinin expression in blood vessel walls and inflammatory cells"
symptom
focal myositis
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom