Focal myositis of lower extremity responsive to botulinum A toxin.

[focal myositis]

Focal myositis is a rare , mostly benign disease (pseudotumor ) of skeletal muscle , histopathologically characterized by interstitial myositis and tumorous enlargement of a single muscle . The etiology of focal myositis remains unknown ; however , localized myopathy has been postulated to be caused by denervation lesions . This case report describes a patient that presented with clinical , laboratory , electromyoneurography , and magnetic resonance imaging features of focal myositis complicated with intervertebral disk protrusion in the lumbosacral spine affected with radicular distress . In most cases , focal myositic lesions show spontaneous regression , relapses are rare , and long -term prognosis is good . There is a wide spectrum of therapeutic options , from no therapy at all through nonsteroidal antirheumatics and glucocorticoids to radiotherapy , surgical excision , and immunosuppressants . In the patient presented , treatment with glucocorticoids , methotrexate , and surgical excision failed to produce satisfactory results . Clinical improvement , pain relief , and reduction in lower leg volume were only achieved by local infiltration of botulinum A toxin .

Diseases
Validation

Diseases presenting "wide spectrum" symptom

22q11.2 deletion syndrome

acute rheumatic fever

adrenal incidentaloma

adrenomyeloneuropathy

alexander disease

allergic bronchopulmonary aspergillosis

canavan disease

classical phenylketonuria

focal myositis

holt-oram syndrome

homocystinuria without methylmalonic aciduria

hydrocephalus with stenosis of the aqueduct of sylvius

kabuki syndrome

kallmann syndrome

krabbe disease

lamellar ichthyosis

monosomy 21

neonatal adrenoleukodystrophy

oligodontia

primary hyperoxaluria type 1

proteus syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

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