[Familial Mediterranean fever - first experiences in Slovakia].

[familial mediterranean fever]

Familial Mediterranean fever (FMF ) is the most prevalent genetically determined autoinflammatory disease . FMF significantly decreases the quality of life and limits life expectancy due to the development of amyloidosis in affected individuals . Prevalence of FMF is highest in the south-eastern Mediterraneans . In other parts of the world , its occurance is often restricted to high -risk ethnic groups . In Central Europe , experience with FMF is scarse to none , as in the case of Slovakia , where no cases have been reported , so far . Herein we report the first five patients (3 adults and 2 children , 4 native Slovaks ) in whom the diagnosis of FMF could be confirmed in Slovakia . Our experience demonstrates that FMF does occur in low -risk populations in Central Europe . Due to low prevalence and lack of experience , FMF diagnosis may be significantly delayed (4 .5 -30 years ) and undiagnosed cases are to be expected in our population .

Diseases
Validation

Diseases presenting "fever" symptom

22q11.2 deletion syndrome

acute rheumatic fever

alexander disease

allergic bronchopulmonary aspergillosis

canavan disease

carcinoma of the gallbladder

child syndrome

congenital toxoplasmosis

cushing syndrome

cystinuria

dracunculiasis

erdheim-chester disease

esophageal adenocarcinoma

esophageal carcinoma

familial mediterranean fever

focal myositis

hodgkin lymphoma, classical

lamellar ichthyosis

legionellosis

locked-in syndrome

malignant atrophic papulosis

neonatal adrenoleukodystrophy

neuralgic amyotrophy

oculocutaneous albinism

papillon-lefèvre syndrome

pyomyositis

pyruvate dehydrogenase deficiency

scrub typhus

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

typhoid

waldenström macroglobulinemia

wolf-hirschhorn syndrome

This symptom has already been validated