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Idiopathic uveitis and familial mediterranean Fever: is there any relationship?
[familial mediterranean fever]
Introduction
.
Familial
Mediterranean
fever
(
FMF
)
is
an
auto-
inflammatory
disease
characterized
by
attacks
of
fever
and
polyserositis
.
FMF
is
often
associated
with
other
autoimmune
diseases
such
as
rheumatoid
arthritis
,
polyarteritis
nodosa
(
PAN
)
,
and
Behcet
.
Uveitis
is
an
inflammatory
process
caused
by
underlying
infectious
and
inflammatory
disorders
.
This
study
investigates
the
probable
relationship
between
idiopathic
uveitis
and
FMF
.
Methods
.
Patients
with
idiopathic
uveitis
were
analyzed
for
the
12
most
common
MEFV
mutations
(
P
369
S
,
F
479
L
,
M
680
I
(
G
/
C
)
,
M
680
I
(
G
/
A
)
,
I
692
del
,
M
694
V
,
M
694
I
,
K
695
R
,
V
726
A
,
A
744
S
,
R
761
H
,
E
148
Q
)
by
a
reverse
hybridization
assay
(
FMF
StripAssay
,
Vienna
lab
,
Vienna
,
Austria
)
.
Results
.
12
patients
with
idiopathic
uveitis
were
enrolled
in
this
study
.
10
of
them
were
female
.
The
youngest
patient
was
a
7
-
year
-old
child
and
the
oldest
was
57
.
The
most
common
complaints
of
patients
were
blurred
vision
and
then
eye
redness
.
One
patient
was
heterozygous
for
R
761
H
.
Genetic
analysis
of
the
12
most
common
MEFV
mutations
in
the
patients
with
idiopathic
uveitis
didnot
have
any
positive
results
.
Conclusion
.
According
to
the
analysis
of
the
12
most
common
MEFV
gene
mutations
,
FMF
is
not
an
underlying
cause
of
idiopathic
uveitis
.
On
the
other
hand
,
uveitis
merely
could
not
be
the
first
presentation
of
FMF
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated