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Idiopathic uveitis and familial mediterranean Fever: is there any relationship?
[familial mediterranean fever]
Introduction
.
Familial
Mediterranean
fever
(
FMF
)
is
an
auto-
inflammatory
disease
characterized
by
attacks
of
fever
and
polyserositis
.
FMF
is
often
associated
with
other
autoimmune
diseases
such
as
rheumatoid
arthritis
,
polyarteritis
nodosa
(
PAN
)
,
and
Behcet
.
Uveitis
is
an
inflammatory
process
caused
by
underlying
infectious
and
inflammatory
disorders
.
This
study
investigates
the
probable
relationship
between
idiopathic
uveitis
and
FMF
.
Methods
.
Patients
with
idiopathic
uveitis
were
analyzed
for
the
12
most
common
MEFV
mutations
(
P
369
S
,
F
479
L
,
M
680
I
(
G
/
C
)
,
M
680
I
(
G
/
A
)
,
I
692
del
,
M
694
V
,
M
694
I
,
K
695
R
,
V
726
A
,
A
744
S
,
R
761
H
,
E
148
Q
)
by
a
reverse
hybridization
assay
(
FMF
StripAssay
,
Vienna
lab
,
Vienna
,
Austria
)
.
Results
.
12
patients
with
idiopathic
uveitis
were
enrolled
in
this
study
.
10
of
them
were
female
.
The
youngest
patient
was
a
7
-
year
-old
child
and
the
oldest
was
57
.
The
most
common
complaints
of
patients
were
blurred
vision
and
then
eye
redness
.
One
patient
was
heterozygous
for
R
761
H
.
Genetic
analysis
of
the
12
most
common
MEFV
mutations
in
the
patients
with
idiopathic
uveitis
didnot
have
any
positive
results
.
Conclusion
.
According
to
the
analysis
of
the
12
most
common
MEFV
gene
mutations
,
FMF
is
not
an
underlying
cause
of
idiopathic
uveitis
.
On
the
other
hand
,
uveitis
merely
could
not
be
the
first
presentation
of
FMF
.
Diseases
Validation
Diseases presenting
"uveitis"
symptom
aniridia
coats disease
congenital toxoplasmosis
familial mediterranean fever
This symptom has already been validated