Two elderly cases of familial mediterranean fever with rheumatoid arthritis.

[familial mediterranean fever]

Familial Mediterranean fever (FMF ) is a genetic autoinflammatory disorder that usually develops before 20 Â years of age and is characterized by periodic fever with serositis and arthritis . Both FMF and rheumatoid arthritis (RA ) involve arthritis ; however , their coexistence is rare . We describe two RA patients with an MEFV mutation in exon 2 , who were diagnosed with FMF at an age of over 50 Â years . We also discuss the possibility that MEFV mutations could modulate RA disease activity .

Diseases
Validation

Diseases presenting "arthritis" symptom

acute rheumatic fever

child syndrome

congenital adrenal hyperplasia

cystinuria

familial hypocalciuric hypercalcemia

familial mediterranean fever

focal myositis

harlequin ichthyosis

homocystinuria without methylmalonic aciduria

inclusion body myositis

lamellar ichthyosis

malignant atrophic papulosis

pyomyositis

sneddon syndrome

trochlear dysplasia

typhoid

wiskott-aldrich syndrome

This symptom has already been validated