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Can colchicine response be predicted in familial Mediterranean fever patients?
[familial mediterranean fever]
The
aims
of
this
study
were
to
explore
whether
the
demographic
and
clinical
features
of
paediatric
familial
Mediterranean
fever
(
FMF
)
patients
with
different
colchicine
response
vary
or
not
and
to
determine
whether
colchicine
response
can
be
predicted
in
FMF
patients
.
Files
of
patients
who
have
been
on
colchicine
therapy
for
at
least
6
months
were
retrospectively
evaluated
.
Patients
were
divided
into
two
groups
:
group
I
included
patients
with
no
attacks
after
colchicine
and
group
II
comprised
patients
with
ongoing
attacks
.
Thereafter
group
II
was
further
divided
into
two
groups
according
to
the
reduction
rate
of
attack
frequency
:
group
IIA
(
>
50
%
)
and
group
IIB
(
≤
50
%
)
.
The
study
group
comprised
221
FMF
patients
(
116
females
,
105
males
)
.
There
were
131
patients
in
group
I
and
90
patients
in
group
II
(
54
in
group
IIA
and
36
in
group
IIB
)
.
Leg
pain
and
M
694
V
homozygosity
were
more
frequent
in
group
II
(
P
<
0
.
05
)
.
Final
colchicine
doses
,
disease
severity
scores
and
number
of
patients
with
elevated
acute
phase
reactant
levels
(
attack-free
period
)
were
significantly
higher
and
colchicine
compliance
was
lower
in
group
II
when
compared
with
group
I
(
P
<
0
.
05
)
.
Erysipelas
-like
erythema
(
ELE
)
,
leg
pain
and
protracted
arthritis
/
protracted
febrile
myalgia
/
vasculitis
were
more
frequently
detected
in
group
IIB
(
P
<
0
.
05
)
.
Colchicine
response
is
excellent
in
the
majority
of
FMF
patients
,
however
,
colchicine
unresponsiveness
can
not
be
predicted
easily
at
onset
.
More
rarely
encountered
clinical
findings
such
as
ELE
,
leg
pain
and
protracted
complaints
and
M
694
V
homozygosity
may
be
a
clue
for
less
colchicine
response
.
Diseases
Validation
Diseases presenting
"erythema"
symptom
acute rheumatic fever
cowden syndrome
cutaneous mastocytosis
epidermolysis bullosa simplex
erythropoietic protoporphyria
familial mediterranean fever
harlequin ichthyosis
inclusion body myositis
kindler syndrome
lamellar ichthyosis
legionellosis
liposarcoma
malignant atrophic papulosis
neuralgic amyotrophy
omenn syndrome
pyomyositis
thoracic outlet syndrome
This symptom has already been validated