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The impact of familial Mediterranean fever on reproductive system.
[familial mediterranean fever]
Familial
Mediterranean
fever
(
FMF
)
is
an
autosomal
recessive
disease
characterized
by
recurrent
attacks
of
fever
,
peritonitis
,
pleuritis
,
arthritis
,
or
erysipelas
-like
skin
lesion
.
FMF
is
the
most
common
periodic
febrile
syndrome
affecting
more
than
150
,
000
people
worldwide
.
The
majority
of
patients
develop
FMF
before
the
age
of
20
.
FMF
may
cause
amyloidosis
,
which
mainly
affects
the
kidneys
but
may
also
be
accumulated
in
other
organs
such
as
the
heart
,
gastrointestinal
tract
,
and
reproductive
organs
.
FMF
being
a
systemic
disorder
with
a
risk
for
amyloidosis
,
affecting
patients
in
their
childbearing
years
,
and
with
its
lifelong
colchicine
therapy
raises
concern
about
its
effect
on
the
reproductive
system
.
In
this
article
,
we
review
the
impact
of
FMF
and
its
treatment
to
the
reproductive
system
of
male
and
female
patients
,
pregnancy
,
and
lactation
.
Diseases
Validation
Diseases presenting
"peritonitis"
symptom
familial mediterranean fever
focal myositis
hirschsprung disease
malignant atrophic papulosis
papillon-lefèvre syndrome
pyomyositis
typhoid
This symptom has already been validated