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Assessment of renal involvement in patients with familial Mediterranean fever: a clinical study from Ardabil, Iran.
[familial mediterranean fever]
Familial
Mediterranean
fever
(
FMF
)
is
an
autosomal
recessive
disease
characterised
by
recurrent
episodes
of
painful
inflammation
in
the
abdomen
,
chest
or
joints
.
The
association
between
FMF
and
non-amyloid
glomerulopathies
are
unusual
.
In
this
study
,
we
describe
our
experiences
and
observations
about
renal
involvement
in
patients
with
FMF
.
A
total
of
108
patients
with
FMF
was
enrolled
in
the
study
.
Twelve
patients
with
FMF
were
referred
to
the
Nephrology
Service
,
for
evaluation
and
assessment
of
the
degree
of
renal
involvement
.
All
the
12
patients
underwent
percutaneous
ultrasound-guided
renal
biopsies
and
genetic
analysis
.
On
microscopic
examination
of
the
kidney
specimens
,
six
patients
were
found
to
have
amyloidosis
,
five
focal
segmental
glomerulosclerosis
and
one
patient
membranoproliferative
glomerulonephritis
.
It
seems
that
in
patients
with
FMF
and
renal
amyloidosis
,
the
response
to
treatment
with
colchicine
is
excellent
,
but
in
patients
with
FMF
and
focal
segmental
glomerulosclerosis
,
the
response
to
treatment
with
colchicine
is
poor
.
We
present
an
evidence-based
algorithm
,
constructed
based
on
literature
review
,
to
aid
decision
making
in
management
of
renal
involvement
in
patients
with
FMF
.
T
he
results
of
our
study
suggest
that
in
patients
with
FMF
and
renal
involvement
,
non-amyloid
renal
lesions
should
be
considered
in
the
differential
diagnosis
in
addition
to
amyloidosis
.
Diseases
Validation
Diseases presenting
"the response to treatment with colchicine is poor"
symptom
familial mediterranean fever
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