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Cardiovascular and metabolic risk factors in inherited autoinflammation.
[familial mediterranean fever]
The
natural
progression
of
metabolic
abnormalities
among
patients
with
inherited
autoinflammation
is
unclear
.
The
objective
of
the
study
was
to
assess
the
cardiometabolic
risk
of
participants
with
familial
Mediterranean
fever
(
FMF
)
.
This
study
included
nationwide
cross-sectional
and
longitudinal
cohorts
.
The
prevalence
of
components
of
the
metabolic
syndrome
at
age
17
years
was
assessed
from
the
medical
database
of
the
Israeli
Defense
Force
from
1973
through
1997
.
Included
were
745
males
with
FMF
,
902
healthy
male
siblings
,
and
a
control
group
of
787
,
714
participants
.
A
prospective
follow-up
study
traced
the
incidence
of
components
of
the
metabolic
syndrome
to
age
45
years
among
57
FMF
and
1568
control
army
personnel
participants
.
Body
mass
index
(
BMI
)
and
blood
pressure
(
BP
)
were
measured
at
age
17
years
(
cross-sectional
)
;
lifestyle
,
anthropometric
,
and
biochemical
data
were
periodically
recorded
from
age
25
years
.
Abnormal
BMI
or
BP
(
age
17
y
)
and
Adult
Treatment
Panel
III
criteria
of
the
metabolic
syndrome
were
measured
.
In
multivariable
regression
analysis
adjusted
for
known
confounders
of
obesity
,
FMF
participants
had
an
odds
ratio
of
0
.
65
for
the
occurrence
of
overweight
[
95
%
confidence
interval
(
CI
)
0
.
44
-
0
.
96
,
P
=
.
03
]
and
0
.
66
(
95
%
CI
0
.
48
-
0
.
92
,
P
=
.
012
)
for
hypertension
-range
BP
;
their
siblings
tended
to
obesity
(
odds
ratio
1
.
48
;
95
%
CI
1
.
04
-
2
.
11
,
P
=
.
008
)
.
In
the
follow-up
arm
,
a
multivariable
analysis
adjusted
for
age
,
birth
year
,
BMI
,
education
,
socioeconomic
status
,
ethnicity
,
and
physical
activity
yielded
hazard
ratios
of
0
.
32
(
95
%
CI
0
.
10
-
0
.
82
,
P
=
.
002
)
for
incident
obesity
,
0
.
49
(
95
%
CI
0
.
25
-
0
.
95
,
P
=
.
037
)
for
incident
triglycerides
150
mg
/
dL
or
greater
,
0
.
56
(
95
%
CI
0
.
31
-
0
.
98
,
P
=
.
048
)
for
low
-density
lipoprotein
cholesterol
130
mg
/
dL
or
greater
,
and
2
.
14
(
1
.
368
-
3
.
359
,
P
=
.
001
)
for
high
-density
lipoprotein
cholesterol
less
than
40
mg
/
dL
for
FMF
participants
compared
with
controls
.
Incident
elevated
BP
was
lower
among
FMF
participants
(
hazard
ratio
0
.
49
;
95
%
CI
0
.
23
-
1
.
00
,
P
=
.
05
)
,
whereas
dysglycemia
incidence
was
comparable
.
FMF
is
associated
with
lower
rates
of
most
components
of
the
metabolic
syndrome
compared
with
normal
subjects
,
unlike
other
inflammatory
conditions
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated