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Cardiovascular and metabolic risk factors in inherited autoinflammation.
[familial mediterranean fever]
The
natural
progression
of
metabolic
abnormalities
among
patients
with
inherited
autoinflammation
is
unclear
.
The
objective
of
the
study
was
to
assess
the
cardiometabolic
risk
of
participants
with
familial
Mediterranean
fever
(
FMF
)
.
This
study
included
nationwide
cross-sectional
and
longitudinal
cohorts
.
The
prevalence
of
components
of
the
metabolic
syndrome
at
age
17
years
was
assessed
from
the
medical
database
of
the
Israeli
Defense
Force
from
1973
through
1997
.
Included
were
745
males
with
FMF
,
902
healthy
male
siblings
,
and
a
control
group
of
787
,
714
participants
.
A
prospective
follow-up
study
traced
the
incidence
of
components
of
the
metabolic
syndrome
to
age
45
years
among
57
FMF
and
1568
control
army
personnel
participants
.
Body
mass
index
(
BMI
)
and
blood
pressure
(
BP
)
were
measured
at
age
17
years
(
cross-sectional
)
;
lifestyle
,
anthropometric
,
and
biochemical
data
were
periodically
recorded
from
age
25
years
.
Abnormal
BMI
or
BP
(
age
17
y
)
and
Adult
Treatment
Panel
III
criteria
of
the
metabolic
syndrome
were
measured
.
In
multivariable
regression
analysis
adjusted
for
known
confounders
of
obesity
,
FMF
participants
had
an
odds
ratio
of
0
.
65
for
the
occurrence
of
overweight
[
95
%
confidence
interval
(
CI
)
0
.
44
-
0
.
96
,
P
=
.
03
]
and
0
.
66
(
95
%
CI
0
.
48
-
0
.
92
,
P
=
.
012
)
for
hypertension
-range
BP
;
their
siblings
tended
to
obesity
(
odds
ratio
1
.
48
;
95
%
CI
1
.
04
-
2
.
11
,
P
=
.
008
)
.
In
the
follow-up
arm
,
a
multivariable
analysis
adjusted
for
age
,
birth
year
,
BMI
,
education
,
socioeconomic
status
,
ethnicity
,
and
physical
activity
yielded
hazard
ratios
of
0
.
32
(
95
%
CI
0
.
10
-
0
.
82
,
P
=
.
002
)
for
incident
obesity
,
0
.
49
(
95
%
CI
0
.
25
-
0
.
95
,
P
=
.
037
)
for
incident
triglycerides
150
mg
/
dL
or
greater
,
0
.
56
(
95
%
CI
0
.
31
-
0
.
98
,
P
=
.
048
)
for
low
-density
lipoprotein
cholesterol
130
mg
/
dL
or
greater
,
and
2
.
14
(
1
.
368
-
3
.
359
,
P
=
.
001
)
for
high
-density
lipoprotein
cholesterol
less
than
40
mg
/
dL
for
FMF
participants
compared
with
controls
.
Incident
elevated
BP
was
lower
among
FMF
participants
(
hazard
ratio
0
.
49
;
95
%
CI
0
.
23
-
1
.
00
,
P
=
.
05
)
,
whereas
dysglycemia
incidence
was
comparable
.
FMF
is
associated
with
lower
rates
of
most
components
of
the
metabolic
syndrome
compared
with
normal
subjects
,
unlike
other
inflammatory
conditions
.
Diseases
Validation
Diseases presenting
"fmf participants had an odds ratio of 0"
symptom
familial mediterranean fever
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