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A random Abstract
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Efficacy of Interleukin-1 Targeting Treatments in Patients with Familial Mediterranean Fever.
[familial mediterranean fever]
Herein
,
we
reported
our
experience
in
colchicine-resistant
familial
Mediterranean
fever
(
FMF
)
patients
who
are
treated
with
anti-interleukin-
1
(
IL
-
1
)
drugs
.
A
retrospective
review
of
medical
records
of
anti-
IL
-
1
recipients
was
performed
.
The
main
clinical
characteristics
of
these
patients
and
the
evolution
after
anti-
IL
-
1
were
recorded
.
There
were
20
patients
(
11
male
[
M
]
and
9
female
[
F
]
)
.
Despite
regular
colchicine
treatment
,
median
number
of
attacks
per
month
and
per
year
was
1
(
1
-
4
)
and
12
(
4
-
50
)
,
respectively
.
Twelve
patients
were
receiving
anakinra
,
and
eight
patients
were
treated
with
canakinumab
.
The
number
of
monthly
and
yearly
attacks
after
IL
-
1
treatment
was
significantly
decreased
after
the
biologic
agent
(
p
 
<
 
0
.
05
)
.
One
patient
did
not
respond
to
the
treatment
,
and
one
patient
developed
serious
infection
during
anti-
IL
-
1
.
We
also
observed
a
significant
decrease
in
proteinuria
in
the
amyloidosis
complicated
FMF
patients
.
Anti-
IL
-
1
targeting
drugs
seem
safe
and
effective
therapies
in
colchicine-resistant
FMF
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated
