P wave dispersion and QT dispersion in adult Turkish migrants with familial mediterranean fever living in Germany.

[familial mediterranean fever]

Familial Mediterranean Fever (FMF ) is a hereditary autoinflammatory disease associated with subclinical inflammation , which includes atherosclerosis arising from endothelial inflammation , which in turn increases the risk of atrial or ventricular arrhythmias . Conduction abnormalities can be detected using the electrocardiographic (ECG ) indices P and QT dispersion (Pdisp and QTdisp ). Currently , it is unknown whether patients with FMF are more likely to have abnormalities of these ECG indices . Moreover , existing studies were conducted in countries with higher FMF prevalence . We therefore perform the first prospective study assessing Pdisp and QTdisp in adult FMF patients in Germany , where prevalence of FMF is low .Asymptomatic FMF patients (n =30 ) of Turkish ancestry living in Germany and age-matched healthy controls (n =37 ) were prospectively assessed using 12 -lead ECG .Patients and controls were comparable in gender and body mass index , and patients had higher erythrocyte sedimentation rate (ESR ), C-reactive protein (CRP ) and serum amyloid A (SAA ) compared to controls (ESR : 23 .7 Â±14 .3 vs . 16 .1 Â±13 ,3 mm /1 (st )h , p =0 .03 , CRP : 0 .73 Â±0 .9 vs . 0 .26 Â±0 .4 g /dl , p =0 .01 , SAA : 3 .14 Â±4 ,8 vs . 0 .37 Â±0 .3 mg /dl , p <0 .01 ). No statistically significant difference between patients and controls respectively , for Pdisp (43 .7 Â±11 .9 vs . 47 .1 Â±11 .2 ms , p =0 .23 ), QTdisp (65 .9 Â±12 .3 vs . 67 .6 Â±12 .7 ms , p =0 .58 ) or corrected QTdisp (cQTdisp : 73 .9 Â±15 .0 vs . 76 .0 Â±13 .3 ms , p =0 .55 ) was found . No correlation could be found between Pdisp or QTdisp or cQTdisp and any of the biochemical markers of inflammation .FMF patients living in Germany show a Pdisp and QTdisp comparable to healthy controls , with no increased risk of atrial or ventricular arrhythmias indicated .

Diseases
Validation

Diseases presenting "ventricular arrhythmias" symptom

fabry disease

familial mediterranean fever

This symptom has already been validated