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Usefulness of mean platelet volume and neutrophil-to-lymphocyte ratio for evaluation of children with Familial Mediterranean fever.
[familial mediterranean fever]
Familial
Mediterranean
fever
(
FMF
)
is
an
autoinflammatory
disease
characterized
by
recurrent
attacks
of
serositis
,
fever
,
and
rash
.
Clinical
and
subclinical
inflammatory
processes
may
contribute
to
atherosclerosis
in
FMF
patients
,
with
mean
platelet
volume
(
MPV
)
as
a
potential
indicator
for
atherosclerosis
risk
and
neutrophil-
to
-lymphocyte
ratio
(
NLR
)
as
a
marker
for
subclinical
inflammation
in
these
patients
.
In
this
study
,
we
investigated
whether
MPV
can
be
used
as
an
indicator
for
atherosclerosis
risk
and
if
NLR
is
a
marker
for
subclinical
inflammation
in
FMF
patients
.
The
study
consisted
of
75
FMF
patients
in
attack
,
157
attack-free
patients
,
and
77
healthy
controls
.
White
blood
cell
count
neutrophil-
to
-lymphocyte
ratio
,
platelet
count
,
MPV
,
PDW
C-
reactive
protein
levels
,
and
erythrocyte
sedimentation
rate
were
recorded
.
There
were
no
significant
differences
between
attack
,
attack-free
,
and
control
groups
in
terms
of
mean
MPV
and
PDW
value
.
NLR
value
was
higher
in
the
attack
group
.
NLR
value
was
similar
in
attack-free
and
control
groups
.
We
found
that
MPV
and
PDW
values
are
similar
in
FMF
patients
and
healthy
controls
.
NLR
was
higher
in
FMF
patients
in
the
attack
period
.
Therefore
,
our
results
suggest
that
MPV
and
PDW
values
do
not
predict
atherosclerosis
risk
in
pediatric
FMF
patients
,
and
NLR
may
be
an
indicator
for
attack
period
but
not
attack-free
period
.
Diseases
Validation
Diseases presenting
"not attack-free period"
symptom
familial mediterranean fever
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