Usefulness of mean platelet volume and neutrophil-to-lymphocyte ratio for evaluation of children with Familial Mediterranean fever.

[familial mediterranean fever]

Familial Mediterranean fever (FMF ) is an autoinflammatory disease characterized by recurrent attacks of serositis , fever , and rash . Clinical and subclinical inflammatory processes may contribute to atherosclerosis in FMF patients , with mean platelet volume (MPV ) as a potential indicator for atherosclerosis risk and neutrophil-to -lymphocyte ratio (NLR ) as a marker for subclinical inflammation in these patients . In this study , we investigated whether MPV can be used as an indicator for atherosclerosis risk and if NLR is a marker for subclinical inflammation in FMF patients .The study consisted of 75 FMF patients in attack , 157 attack-free patients , and 77 healthy controls . White blood cell count neutrophil-to -lymphocyte ratio , platelet count , MPV , PDW C-reactive protein levels , and erythrocyte sedimentation rate were recorded .There were no significant differences between attack , attack-free , and control groups in terms of mean MPV and PDW value . NLR value was higher in the attack group . NLR value was similar in attack-free and control groups .We found that MPV and PDW values are similar in FMF patients and healthy controls . NLR was higher in FMF patients in the attack period . Therefore , our results suggest that MPV and PDW values do not predict atherosclerosis risk in pediatric FMF patients , and NLR may be an indicator for attack period but not attack-free period .

Diseases
Validation

Diseases presenting "white blood cell count" symptom

esophageal squamous cell carcinoma

familial mediterranean fever

pyomyositis

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