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The coincidence of familial mediterranean Fever and hypereosinophilia in a patient with hereditary elliptocytosis.
[familial mediterranean fever]
Familial
Mediterranean
fever
(
FMF
)
is
a
genetic
disease
with
autosomal
inheritance
characterized
by
recurrent
fever
,
abdominal
pain
,
and
serositis
attacks
.
It
is
relatively
common
in
the
races
and
ethnical
groups
around
Mediterranean
Sea
(
Sephardic
Jews
,
Armenians
,
Turks
and
Arabians
)
.
Hereditary
elliptocytosis
(
HE
)
is
common
genetic
defect
of
the
red
blood
cell
membrane
skeleton
.
Spectrin
mutations
are
the
predominant
causes
of
HE
.
Hypereosinophilia
is
defined
as
a
number
of
eosinophil
granulocytes
equal
or
greater
than
0
.
5
Â
×
Â
10
(
9
)
/
L
of
circulating
blood
.
The
main
causes
are
allergies
and
parasitic
infections
.
This
case
report
describes
a
Turkish
female
HE
patient
who
presented
with
FMF
and
hypereosinophilia
.
Genetic
analysis
revealed
heterozygous
mutation
in
exon
10
of
the
MEFV
gene
(
V
726
A
)
.
The
patient
was
successfully
treated
with
colchicine
and
steroid
treatment
at
3
-
month
follow-up
.
To
the
best
of
our
knowledge
,
this
is
the
first
report
of
association
between
FMF
,
HE
,
and
hypereosinophilia
.
