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Sonographic assessment of spleen size in Turkish migrants with familial mediterranean Fever in Germany.
[familial mediterranean fever]
Familial
Mediterranean
fever
(
FMF
)
can
be
associated
with
splenomegaly
.
Prospective
quantitative
data
are
lacking
.
We
performed
a
sonographic
assessment
of
spleen
size
in
patients
with
FMF
and
healthy
control
participants
to
assess
its
diagnostic
value
.
Patients
with
FMF
according
to
the
criteria
of
Livneh
et
al
(
Arthritis
Rheum
1997
;
40
:
1879
-
1885
)
who
were
in
an
asymptomatic
interval
and
control
participants
were
prospectively
included
in
this
study
in
Germany
and
underwent
sonographic
measurement
of
the
spleen
as
well
as
a
structured
interview
and
a
physical
examination
.
Patients
and
controls
were
Turkish
migrants
.
Thirty
-
six
patients
and
27
controls
were
included
.
Patients
and
controls
did
not
differ
significantly
in
age
(
mean
±
SD
,
34
.
8
±
9
.
7
versus
33
.
3
±
10
.
0
years
,
respectively
;
P
=
.
56
)
,
sex
,
height
,
weight
,
or
body
mass
index
(
26
.
7
±
4
.
7
versus
26
.
1
±
4
.
3
kg
/
m
(
2
)
;
P
=
.
63
)
.
Spleen
size
was
greater
in
patients
than
controls
in
width
(
4
.
3
±
1
.
0
versus
3
.
7
±
0
.
7
cm
;
P
=
.
008
)
and
also
length
(
12
.
1
±
1
.
9
versus
10
.
5
±
1
.
4
cm
;
P
=
.
001
)
.
Twenty
-
six
of
36
patients
(
72
.
2
%
)
had
a
history
of
appendectomy
compared
to
3
of
27
controls
(
11
.
1
%
;
P
<
.
001
)
.
The
combination
of
an
enlarged
spleen
(
length
>
11
cm
and
/
or
width
>
4
cm
)
gave
specificity
of
100
%
(
95
%
confidence
interval
,
87
%
-
100
%
)
and
a
positive
predictive
value
of
100
%
(
95
%
confidence
interval
,
78
%
-
100
%
)
for
the
diagnosis
of
FMF
in
our
study
.
Spleen
size
as
evaluated
by
sonography
is
larger
in
patients
with
FMF
compared
to
healthy
controls
.
Most
patients
with
FMF
included
in
this
study
had
undergone
appendectomy
.
Familial
Mediterranean
fever
should
be
considered
as
a
differential
diagnosis
in
Turkish
migrants
in
Germany
if
the
spleen
is
enlarged
and
a
history
of
appendectomy
is
reported
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated
