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Sonographic assessment of spleen size in Turkish migrants with familial mediterranean Fever in Germany.
[familial mediterranean fever]
Familial
Mediterranean
fever
(
FMF
)
can
be
associated
with
splenomegaly
.
Prospective
quantitative
data
are
lacking
.
We
performed
a
sonographic
assessment
of
spleen
size
in
patients
with
FMF
and
healthy
control
participants
to
assess
its
diagnostic
value
.
Patients
with
FMF
according
to
the
criteria
of
Livneh
et
al
(
Arthritis
Rheum
1997
;
40
:
1879
-
1885
)
who
were
in
an
asymptomatic
interval
and
control
participants
were
prospectively
included
in
this
study
in
Germany
and
underwent
sonographic
measurement
of
the
spleen
as
well
as
a
structured
interview
and
a
physical
examination
.
Patients
and
controls
were
Turkish
migrants
.
Thirty
-
six
patients
and
27
controls
were
included
.
Patients
and
controls
did
not
differ
significantly
in
age
(
mean
±
SD
,
34
.
8
±
9
.
7
versus
33
.
3
±
10
.
0
years
,
respectively
;
P
=
.
56
)
,
sex
,
height
,
weight
,
or
body
mass
index
(
26
.
7
±
4
.
7
versus
26
.
1
±
4
.
3
kg
/
m
(
2
)
;
P
=
.
63
)
.
Spleen
size
was
greater
in
patients
than
controls
in
width
(
4
.
3
±
1
.
0
versus
3
.
7
±
0
.
7
cm
;
P
=
.
008
)
and
also
length
(
12
.
1
±
1
.
9
versus
10
.
5
±
1
.
4
cm
;
P
=
.
001
)
.
Twenty
-
six
of
36
patients
(
72
.
2
%
)
had
a
history
of
appendectomy
compared
to
3
of
27
controls
(
11
.
1
%
;
P
<
.
001
)
.
The
combination
of
an
enlarged
spleen
(
length
>
11
cm
and
/
or
width
>
4
cm
)
gave
specificity
of
100
%
(
95
%
confidence
interval
,
87
%
-
100
%
)
and
a
positive
predictive
value
of
100
%
(
95
%
confidence
interval
,
78
%
-
100
%
)
for
the
diagnosis
of
FMF
in
our
study
.
Spleen
size
as
evaluated
by
sonography
is
larger
in
patients
with
FMF
compared
to
healthy
controls
.
Most
patients
with
FMF
included
in
this
study
had
undergone
appendectomy
.
Familial
Mediterranean
fever
should
be
considered
as
a
differential
diagnosis
in
Turkish
migrants
in
Germany
if
the
spleen
is
enlarged
and
a
history
of
appendectomy
is
reported
.
