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Native kidney biopsies in Armenian and Swiss children: high prevalence of amyloidosis in Yerevan and of IgA nephropathy in Zurich.
[familial mediterranean fever]
The
spectrum
of
pathology
in
native
kidney
biopsies
varies
considerably
between
different
countries
.
Based
on
similar
biopsy
policy
and
joint
workup
,
biopsy
data
of
native
kidneys
of
children
in
Yerevan
(
Armenia
)
and
Zurich
(
Switzerland
)
were
compared
over
a
period
of
two
decades
(
1993
-
2002
and
2003
-
2012
)
.
A
total
of
487
renal
biopsies
in
Yerevan
(
EVN
)
,
n
 
=
 
253
;
median
age
11
.
2
Â
years
(
range
0
.
8
-
18
;
56
Â
%
males
)
and
in
Zurich
(
ZRH
)
,
n
 
=
 
234
;
median
age
8
.
7
Â
years
(
range
0
.
1
-
18
;
61
Â
%
males
)
were
analyzed
.
Biopsies
from
EVN
were
locally
analyzed
by
light
microscopy
(
LM
)
and
sent
to
ZRH
for
electron
microscopy
(
EM
)
and
immunohistochemistry
.
Biopsies
from
ZRH
were
evaluated
by
LM
,
EM
,
and
immunofluorescence
.
The
significant
difference
concerns
the
high
frequency
of
amyloidosis
in
EVN
(
25
.
4
Â
%
in
the
first
and
19
.
4
Â
%
in
the
second
decade
vs
.
0
Â
%
in
ZRH
)
and
of
IgA
nephropathy
in
ZRH
(
30
.
2
Â
%
in
the
first
and
26
.
1
Â
%
in
the
second
decade
vs
.
8
.
1
in
EVN
)
.
Certain
forms
of
glomerulonephritis
(
membranoproliferative
type
I
and
membranous
)
and
primary
focal
segmental
glomerulosclerosis
tended
to
be
more
frequent
in
EVN
than
in
ZRH
.
Amyloid
nephropathy
due
to
familial
Mediterranean
fever
is
still
highly
frequent
in
Armenia
with
a
slight
decrease
in
the
second
decade
.
In
Switzerland
,
the
most
common
finding
was
IgA
nephropathy
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated
