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Native kidney biopsies in Armenian and Swiss children: high prevalence of amyloidosis in Yerevan and of IgA nephropathy in Zurich.
[familial mediterranean fever]
The
spectrum
of
pathology
in
native
kidney
biopsies
varies
considerably
between
different
countries
.
Based
on
similar
biopsy
policy
and
joint
workup
,
biopsy
data
of
native
kidneys
of
children
in
Yerevan
(
Armenia
)
and
Zurich
(
Switzerland
)
were
compared
over
a
period
of
two
decades
(
1993
-
2002
and
2003
-
2012
)
.
A
total
of
487
renal
biopsies
in
Yerevan
(
EVN
)
,
n
 
=
 
253
;
median
age
11
.
2
Â
years
(
range
0
.
8
-
18
;
56
Â
%
males
)
and
in
Zurich
(
ZRH
)
,
n
 
=
 
234
;
median
age
8
.
7
Â
years
(
range
0
.
1
-
18
;
61
Â
%
males
)
were
analyzed
.
Biopsies
from
EVN
were
locally
analyzed
by
light
microscopy
(
LM
)
and
sent
to
ZRH
for
electron
microscopy
(
EM
)
and
immunohistochemistry
.
Biopsies
from
ZRH
were
evaluated
by
LM
,
EM
,
and
immunofluorescence
.
The
significant
difference
concerns
the
high
frequency
of
amyloidosis
in
EVN
(
25
.
4
Â
%
in
the
first
and
19
.
4
Â
%
in
the
second
decade
vs
.
0
Â
%
in
ZRH
)
and
of
IgA
nephropathy
in
ZRH
(
30
.
2
Â
%
in
the
first
and
26
.
1
Â
%
in
the
second
decade
vs
.
8
.
1
in
EVN
)
.
Certain
forms
of
glomerulonephritis
(
membranoproliferative
type
I
and
membranous
)
and
primary
focal
segmental
glomerulosclerosis
tended
to
be
more
frequent
in
EVN
than
in
ZRH
.
Amyloid
nephropathy
due
to
familial
Mediterranean
fever
is
still
highly
frequent
in
Armenia
with
a
slight
decrease
in
the
second
decade
.
In
Switzerland
,
the
most
common
finding
was
IgA
nephropathy
.
Diseases
Validation
Diseases presenting
"renal biopsies"
symptom
familial mediterranean fever
sneddon syndrome
systemic capillary leak syndrome
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