Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Coordinated control of renal Ca(2+) transport proteins by parathyroid hormone.
[familial hypocalciuric hypercalcemia]
The
kidney
is
one
of
the
affected
organs
involved
in
the
clinical
symptoms
of
parathyroid
hormone
(
PTH
)
-
related
disorders
,
like
primary
hyperparathyroidism
and
familial
hypocalciuric
hypercalcemia
.
The
molecular
mechanism
(
s
)
underlying
alterations
in
renal
Ca
(
2
+
)
handling
in
these
disorders
is
poorly
understood
.
Parathyroidectomized
and
PTH
-supplemented
rats
and
mice
infused
with
the
calcimimetic
compound
NPS
R-
467
were
used
to
study
the
in
vivo
effect
of
PTH
on
the
expression
of
renal
transcellular
Ca
(
2
+
)
transport
proteins
,
including
the
epithelial
Ca
(
2
+
)
channel
transient
receptor
potential
,
vanilloid
,
member
5
(
TRPV
5
)
,
calbindins
,
and
the
Na
(
+
)
/
Ca
(
2
+
)
-
exchanger
(
NCX
1
)
.
In
addition
,
the
effect
of
PTH
on
transepithelial
Ca
(
2
+
)
transport
in
rabbit
connecting
tubule
/
cortical
collecting
duct
(
CNT
/
CCD
)
primary
cultures
was
determined
.
Decreased
PTH
levels
in
parathyroidectomized
rats
or
NPS
R-
467
-
infused
mice
,
resulted
in
reduced
expression
of
these
proteins
,
which
is
consistent
with
diminished
Ca
(
2
+
)
reabsorption
,
causing
the
development
of
the
observed
hypocalcemia
.
PTH
supplementation
of
parathyroidectomized
rats
restored
the
expression
of
the
renal
Ca
(
2
+
)
transport
machinery
and
serum
Ca
(
2
+
)
levels
,
independent
of
serum
1
,
25
-
dihydroxyvitamin
D
(
3
)
levels
and
renal
vitamin
D
or
Ca
(
2
+
)
-
sensing
receptor
mRNA
abundance
.
Inhibition
of
the
PTH
-stimulated
transepithelial
Ca
(
2
+
)
transport
by
the
TRPV
5
-
specific
inhibitor
ruthenium
red
reduced
the
PTH
-stimulated
expression
of
calbindin-
D
(
28
K
)
and
NCX
1
in
rabbit
CNT
/
CCD
primary
cultures
.
PTH
stimulates
renal
Ca
(
2
+
)
reabsorption
through
the
coordinated
expression
of
renal
transcellular
Ca
(
2
+
)
transport
proteins
.
Moreover
,
the
PTH
-induced
stimulation
is
enhanced
by
the
magnitude
of
the
Ca
(
2
+
)
influx
through
the
gatekeeper
TRPV
5
,
which
in
turn
facilitates
the
expression
of
the
downstream
Ca
(
2
+
)
transport
proteins
.
Therefore
,
the
renal
transcellular
Ca
(
2
+
)
transport
proteins
,
including
TRPV
5
,
could
contribute
to
the
pathogenesis
of
PTH
-related
disorders
.
Diseases
Validation
Diseases presenting
"primary cultures"
symptom
alexander disease
familial hypocalciuric hypercalcemia
monosomy 21
pyruvate dehydrogenase deficiency
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom
