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Clinical signs in young patients with stroke related to FAST: results of the sifap1 study.
[fabry disease]
The
present
study
aimed
to
evaluate
the
frequency
of
warning
signs
in
younger
patients
with
stroke
with
a
special
regard
to
the
'
FAST
'
scheme
,
a
public
stroke
recognition
instrument
(
face
,
arm
,
speech
,
timely
)
.
Primary
stroke
care
in
participating
centres
of
a
multinational
European
prospective
cross-sectional
study
(
Stroke
in
Young
Fabry
Patients
;
sifap
1
)
.
Forty
-
seven
centres
from
15
European
countries
participate
in
sifap
1
.
5023
acute
patients
with
stroke
(
aged
18
-
55
 
years
)
patients
(
96
.
5
%
Caucasians
)
were
enrolled
in
the
study
between
April
2007
and
January
2010
.
sifap
1
was
originally
designed
to
investigate
the
relation
of
juvenile
stroke
and
Fabry
disease
.
A
secondary
aim
of
sifap
1
was
to
investigate
stroke
patterns
in
this
specific
group
of
patients
.
The
present
investigation
is
a
secondary
analysis
addressing
stroke
presenting
symptoms
with
a
special
regard
to
signs
included
in
the
FAST
scheme
.
4535
patients
with
transient
ischaemic
attack
(
TIA
;
n
=
1071
)
,
ischaemic
stroke
(
n
=
3396
)
or
other
(
n
=
68
)
were
considered
in
the
presented
analysis
.
FAST
symptoms
could
be
traced
in
76
.
5
%
of
all
cases
.
35
%
of
those
with
at
least
one
FAST
symptom
had
all
three
symptoms
.
At
least
one
FAST
symptom
could
be
recognised
in
69
.
1
%
of
18
-
24
 
years
-old
patients
,
in
74
%
of
those
aged
25
-
34
 
years
,
in
75
.
4
%
of
those
aged
35
-
44
 
years
,
and
77
.
8
%
in
45
-
55
 
years
-old
patients
.
With
increasing
stroke
severity
signs
included
in
the
FAST
scheme
were
more
prevalent
(
National
Institute
of
Health
Stroke
Scale
,
NIHSS
<
5
:
69
%
,
NIHSS
6
-
15
:
98
.
9
%
,
NIHSS
>
15
:
100
%
)
.
Clustering
clinical
signs
according
to
FAST
lower
percentages
of
strokes
in
the
posterior
circulation
(
65
.
2
%
)
and
in
patients
with
TIA
(
62
.
3
%
)
were
identified
.
F
AST
may
be
applied
as
a
useful
and
rapid
tool
to
identify
stroke
symptoms
in
young
individuals
aged
18
-
55
 
years
.
Especially
in
patients
eligible
for
thrombolysis
FAST
might
address
the
majority
of
individuals
.
The
study
was
registered
in
http
:
/
/
www
.
clinicaltrials
.
gov
(
No
.
NCT
00414583
)
.
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