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A retrospective study of paclitaxel combining nedaplatin chemotherapy for esophageal cancer.
[esophageal squamous cell carcinoma]
The
aim
of
this
study
was
to
evaluate
the
efficacy
and
tolerability
of
the
combination
of
paclitaxel
and
nedaplatin
in
patients
with
advanced
esophageal
cancer
.
Patients
(
n
=
310
)
with
recurrent
or
metastatic
esophageal
squamous
cell
carcinoma
,
who
had
a
maximum
of
one
previous
chemotherapy
regimen
,
were
enrolled
in
this
study
.
All
patients
had
bidimensionally
measurable
disease
.
Patients
received
175
 
mg
/
m
of
paclitaxel
over
a
3
 
h
infusion
,
followed
by
nedaplatin
80
 
mg
/
m
in
a
1
 
h
infusion
on
day
1
every
3
weeks
for
up
to
6
treatment
cycles
.
The
overall
response
rate
was
47
.
7
%
,
with
complete
and
partial
response
rates
of
6
.
1
and
41
.
7
%
,
respectively
.
The
median
time
to
progression
for
all
patients
was
6
.
8
months
(
95
%
confidence
interval
,
6
.
2
-
7
.
4
months
)
and
the
3
-
year
disease-free
survival
probability
was
3
(
15
.
8
%
)
.
The
major
toxicity
observed
was
cumulative
neutropenia
,
with
29
%
patients
developing
grade
4
toxicity
.
There
was
no
treatment-related
death
.
The
most
common
nonhematologic
toxicity
encountered
with
this
regimen
was
pain
and
cumulative
peripheral
neuropathy
,
with
26
%
patients
experiencing
grade
2
or
3
toxicity
.
The
combination
of
paclitaxel
and
nedaplatin
shows
significant
antitumor
activity
and
a
favorable
toxicity
profile
in
patients
with
metastatic
carcinoma
of
esophageal
cancer
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
