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Is there an association between ABO blood group and overall survival in patients with esophageal squamous cell carcinoma?

[esophageal squamous cell carcinoma]

The relationship between ABO blood group and clinical characteristics had been studied in several cancers. However, its role in esophageal cancer (EC) is unclear. The aim of this study was to determine whether ABO blood group is associated with overall survival in patients with esophageal squamous cell carcinoma (ESCC).From 2005 to 2008, a retrospective analysis of 496 consecutive patients with ESCC was conducted. The relationship between ABO blood group and clinicopathologic features of ESCC was analyzed. Prognostic factors for overall survival of ESCC were also analyzed.The 5-year overall survival of ESCC patients with blood group A, B, AB and O were 47.8%, 44.1%, 43.2%, and 38.4%, respectively (P = 0.165). However, patients with blood group non-O have a better 5-year overall survival than patients with blood group O (45.7% vs. 38.4%; P = 0.043). Multivariate analyses showed ABO blood group (O vs. non-O; P = 0.034) is an independent prognostic factors.ABO blood group is associated with overall survival in patients with ESCC. We concluded that patients with blood group O have a significantly worse overall survival than non-O blood groups.