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A random Abstract
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IL-6-stimulated CD11b+ CD14+ HLA-DR- myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus.
[esophageal squamous cell carcinoma]
The
aim
of
this
study
was
to
assess
the
significance
of
myeloid-derived
suppressor
cells
(
MDSCs
)
and
their
association
with
IL
-
6
in
esophageal
squamous
cell
carcinoma
(
SCC
)
.
We
examined
the
percentage
of
CD
11
b
+
CD
14
+
HLA-
DR
-
myeloid
cells
and
the
levels
of
IL
-
6
in
the
peripheral
blood
of
50
patients
with
esophageal
SCC
and
12
healthy
controls
.
Moreover
,
we
evaluated
the
relationship
between
MDSC
recruitment
,
IL
-
6
levels
,
and
tumor
progression
by
adding
4
-
nitroquinoline
1
-
oxide
(
4
-
NQO
)
to
the
drinking
water
of
mice
to
induce
esophageal
tumors
.
Here
we
demonstrated
that
circulating
CD
11
b
+
CD
14
+
HLA-
DR
-
cells
were
significantly
increased
in
esophageal
SCC
patients
compared
with
healthy
people
,
and
this
was
associated
with
the
clinical
stage
,
treatment
response
and
circulating
IL
-
6
levels
.
In
a
4
-
NQO-induced
esophageal
tumor
animal
model
,
MDSC
recruitment
was
associated
with
invasive
esophageal
tumors
and
with
increased
IL
-
6
levels
.
IL
-
6
stimulated
reactive
oxygen
species
,
arginase
1
and
p
-
STAT
3
in
MDSCs
.
Blockade
of
IL
-
6
prevented
induction
of
MDSCs
and
the
incidence
of
4
-
NQO-
induced
invasive
tumors
.
In
conclusion
,
the
levels
of
MDSCs
and
IL
-
6
predicted
the
prognosis
of
patients
with
esophageal
SCC
.
Moreover
,
we
suggest
inhibition
of
IL
-
6
as
a
potential
strategy
for
the
treatment
of
esophageal
SCC
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated
