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A random Abstract
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Exploration of potential roles of a new LOXL2 splicing variant using network knowledge in esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
LOXL
2
(
lysyl
oxidase-like
2
)
,
an
enzyme
that
catalyzes
oxidative
deamination
of
lysine
residue
,
is
upregulated
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
.
A
LOXL
2
splice
variant
LOXL
2
-
e
13
and
its
wild
type
were
overexpressed
in
ESCC
cells
followed
by
microarray
analyses
.
In
this
study
,
we
explored
the
potential
role
and
molecular
mechanism
of
LOXL
2
-
e
13
based
on
known
protein-protein
interactions
(
PPIs
)
,
following
microarray
analysis
of
KYSE
150
ESCC
cells
overexpressing
a
LOXL
2
splice
variant
,
denoted
by
LOXL
2
-
e
13
,
or
its
wild-
type
counterpart
.
The
differentially
expressed
genes
(
DEGs
)
of
LOXL
2
-
WT
and
LOXL
2
-
e
13
were
applied
to
generate
individual
PPI
subnetworks
in
which
hundreds
of
DEGs
interacted
with
thousands
of
other
proteins
.
These
two
DEG
groups
were
annotated
by
Functional
Annotation
Chart
analysis
in
the
DAVID
bioinformatics
database
and
compared
.
These
results
found
many
specific
annotations
indicating
the
potential
specific
role
or
mechanism
for
LOXL
2
-
e
13
.
The
DEGs
of
LOXL
2
-
e
13
,
comparing
to
its
wild
type
,
were
prioritized
by
the
Random
Walk
with
Restart
algorithm
.
Several
tumor
-related
genes
such
as
ERO
1
L
,
ITGA
3
,
and
MAPK
8
were
found
closest
to
LOXL
2
-
e
13
.
These
results
provide
helpful
information
for
subsequent
experimental
identification
of
the
specific
biological
roles
and
molecular
mechanisms
of
LOXL
2
-
e
13
.
Our
study
also
provides
a
work
flow
to
identify
potential
roles
of
splice
variants
with
large
scale
data
.
Diseases
Validation
Diseases presenting
"known protein-protein interactions"
symptom
esophageal squamous cell carcinoma
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