p53 is an independent prognostic factor in operable esophageal squamous cell carcinoma: a large-scale study with a long follow-up.

[esophageal squamous cell carcinoma]

The p 53 protein is involved in many biological functions in cancer , such as cell cycle arrest , DNA repair , apoptosis , senescence , DNA metabolism , angiogenesis , and cellular differentiation . However , the association between p 53 expression and clinicopathological findings or prognosis in esophageal squamous cell carcinoma (ESCC ) is controversial . We designed a large -scale study of 830 operable ESCC patients with a long follow-up to investigate the relationship between p 53 expression and the clinicopathological characteristics and prognosis of patients . Immunohistochemistry was used to detect p 53 protein expression . When the patients were divided into two groups , a positive expression group and a negative expression group , p 53 -positive expression positively correlated with a poorer differentiation level (P = 0 .044 ). The overexpression of p 53 was associated with a more advanced clinical stage (P = 0 .015 ). A total of 775 patients were available for survival analysis . The median OS of 160 patients who had p 53 -positive expression and 486 patients who had p 53 -negative expression were 58 .8 and 46 .3 months , respectively (P = 0 .021 ); the median PFS of the two groups were 39 .6 and 27 .5 months , respectively (P = 0 .015 ). Lymph node metastasis , gender , differentiation , depth of invasion , and p 53 protein expression were proven to have an influence on both OS and PFS in a univariate analysis . In the multivariate analysis , p 53 -positive expression maintained its independent prognostic impact on OS (P = 0 .048 ) and PFS (P = 0 .039 ), as did lymph node metastasis , differentiation , and depth of invasion . We identified that p 53 protein-positive expression can serve as an independent , unfavorable prognosis biomarker in ESCC .

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Diseases presenting "positive expression group" symptom

esophageal squamous cell carcinoma

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