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ZNF695 methylation predicts a response of esophageal squamous cell carcinoma to definitive chemoradiotherapy.
[esophageal squamous cell carcinoma]
Definitive
chemoradiotherapy
(
dCRT
)
is
one
of
the
standard
treatments
for
esophageal
squamous
cell
carcinoma
.
Patients
with
a
response
to
dCRT
have
a
better
prognosis
than
those
resistant
to
dCRT
while
survival
benefits
for
patients
with
residual
tumors
are
limited
.
Nevertheless
,
few
molecular
markers
to
predict
the
response
to
dCRT
are
currently
available
.
Here
,
we
aimed
to
establish
a
DNA
methylation
marker
to
predict
the
response
to
dCRT
.
A
total
of
104
patients
were
divided
into
screening
(
n
=
43
)
and
validation
(
n
=
61
)
sets
.
A
genome-
wide
DNA
methylation
analysis
was
performed
using
an
Infinium
HumanMethylation
450
BeadChip
array
.
Methylation
levels
were
measured
by
quantitative
methylation-
specific
PCR
and
normalized
by
the
fraction
of
cancer
cells
in
a
sample
.
The
genome-
wide
methylation
analysis
of
seven
responders
and
eight
non-responders
identified
18
genomic
regions
specifically
(
un
)
methylated
in
the
responders
.
Among
these
,
methylation
of
the
promoter
CpG
island
of
ZNF
695
was
significantly
associated
with
the
response
to
dCRT
in
the
screening
set
(
P
=
0
.
004
)
,
and
a
cutoff
value
was
determined
.
In
the
validation
set
,
the
association
was
successfully
validated
(
P
=
0
.
021
)
,
and
a
high
specificity
(
90
%
)
for
the
prediction
of
responders
was
obtained
using
the
prefixed
cutoff
value
.
In
addition
,
a
multivariate
analysis
showed
that
ZNF
695
methylation
was
an
independent
predictive
factor
for
the
response
to
dCRT
(
OR
7
.
55
,
95
%
CI
2
.
12
-
26
.
9
,
P
=
0
.
002
)
.
ZNF
695
methylation
was
significantly
associated
with
the
response
to
dCRT
and
is
a
promising
predictive
marker
for
the
response
to
dCRT
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
