Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Ginsenoside Rg3 enhances the inhibitory effects of chemotherapy on esophageal squamous cell carcinoma in mice.
[esophageal squamous cell carcinoma]
The
present
study
was
conducted
in
order
to
investigate
the
inhibitory
effects
of
ginsenoside
Rg
3
combined
with
chemotherapy
on
Eca-
109
esophageal
squamous
cell
carcinoma
(
ESCC
)
in
mice
.
Tumor
xenograft
models
were
established
in
the
right
forelimb
of
20
BALB
/
c
nude
mice
by
subcutaneous
injection
.
The
tumor
-bearing
mice
were
randomly
assigned
to
4
treatment
groups
(
n
=
5
per
group
)
as
follows
:
the
control
group
(
saline
)
,
the
ginsenoside
Rg
3
alone
group
(
6
mg
/
kg
/
day
,
once
a
day
for
3
weeks
)
,
the
chemotherapy
alone
group
(
paclitaxel
10
mg
/
kg
/
day
+
cisplatin
5
mg
/
kg
/
day
on
days
1
,
7
,
14
and
21
)
and
the
chemotherapy
+
Rg
3
group
(
combined
treatment
)
.
The
length
and
width
of
the
tumor
were
directly
measured
with
calipers
at
different
time
points
and
the
tumor
volume
(
cm
(
3
)
)
was
calculated
using
the
formula
0
.
52
×
length
×
width
(
2
)
every
other
day
.
The
mice
were
sacrificed
by
cervical
dislocation
following
completion
of
therapy
,
the
tumors
were
removed
and
weighed
and
the
expression
levels
of
Ki-
67
were
determined
by
immunohistochemistry
.
The
results
indicated
that
the
coadministration
of
ginsenoside
Rg
3
significantly
enhanced
the
inhibitory
effects
of
chemotherapy
on
tumor
growth
.
In
addition
,
the
expression
levels
of
Ki-
67
in
the
chemotherapy
+
Rg
3
group
were
significantly
lower
compared
to
those
in
the
other
3
groups
.
The
chemotherapy
+
Rg
3
group
also
exhibited
the
lowest
microvascular
density
among
all
four
groups
.
These
findings
suggested
that
ginsenoside
Rg
3
may
improve
the
antitumor
efficacy
of
chemotherapy
in
Eca-
109
ESCC
in
mice
.
Diseases
Validation
Diseases presenting
"right forelimb"
symptom
esophageal carcinoma
esophageal squamous cell carcinoma
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom