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Expression and clinical role of NF45 as a novel cell cycle protein in esophageal squamous cell carcinoma (ESCC).
[esophageal squamous cell carcinoma]
NF
45
(
also
known
as
ILF
2
)
,
as
one
subunit
of
NF-AT
(
nuclear
factor
of
activated
T
cells
)
,
repairs
DNA
breaks
,
inhibits
viral
replication
,
and
also
functions
as
a
negative
regulator
in
the
microRNA
processing
pathway
in
combination
with
NF
90
.
Recently
,
it
was
found
that
implicated
in
the
mitotic
control
of
HeLa
cells
and
deletion
of
endogenous
NF
45
decreases
growth
of
HeLa
cells
.
While
the
role
of
NF
45
in
cancer
biology
remains
under
debate
.
In
this
study
,
we
analyzed
the
expression
and
clinical
significance
of
NF
45
in
esophageal
squamous
cell
carcinoma
ESCC
.
The
expression
of
NF
45
was
evaluated
by
Western
blot
in
8
paired
fresh
ESCC
tissues
and
immunohistochemistry
on
105
paraffin-embedded
slices
.
NF
45
was
highly
expressed
in
ESCC
and
significantly
associated
with
ESCC
cells
tumor
stage
and
Ki-
67
.
Besides
,
high
NF
45
expression
was
an
independent
prognostic
factor
for
ESCC
patients
'
poor
survival
.
To
determine
whether
NF
45
could
regulate
the
proliferation
of
ESCC
cells
,
we
increased
endogenous
NF
45
and
analyzed
the
proliferation
of
TE
1
ESCC
cells
using
Western
blot
,
CCK
8
,
flow
cytometry
assays
and
colony
formation
analyses
,
which
together
indicated
that
overexpression
of
NF
45
favors
cell
cycle
progress
of
TE
1
ESCC
cells
.
While
knockdown
of
NF
45
resulted
in
cell
cycle
arrest
at
G
0
/
G
1
-
phase
and
thus
abolished
the
cell
growth
.
These
findings
suggested
that
NF
45
might
play
an
important
role
in
promoting
the
tumorigenesis
of
ESCC
,
and
thus
be
a
promising
therapeutic
target
to
prevent
ESCC
progression
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated