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Expression of insulin-like growth factor-II mRNA-binding protein-3 as a marker for predicting clinical outcome in patients with esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
Insulin
-like
growth
factor
-
II
mRNA-binding
protein-
3
(
IMP
3
)
is
an
important
factor
in
carcinogenesis
,
although
its
clinical
significance
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
remains
unknown
.
The
present
study
investigated
the
associations
between
IMP
3
expression
and
the
clinicopathological
parameters
.
IMP
3
expression
was
assessed
in
191
resected
ESCC
specimens
,
and
the
associations
between
IMP
3
expression
in
ESCC
,
the
clinicopathological
parameters
and
patient
prognosis
were
examined
.
Using
immunohistochemistry
,
113
(
59
.
2
%
)
tumors
were
identified
as
IMP
3
-
positive
.
IMP
3
positivity
correlated
significantly
with
high
pathological
(
p
)
Stage
,
pT
stage
and
pN
stage
.
The
IMP
3
-
positive
patients
exhibited
a
poorer
prognosis
compared
with
the
IMP
3
-
negative
patients
.
In
univariate
analyses
,
histology
[
hazard
ratio
(
HR
)
,
1
.
94
;
95
%
confidence
interval
(
CI
)
,
1
.
18
-
3
.
49
;
P
=
0
.
0082
]
,
pT
(
HR
,
2
.
34
;
95
%
CI
,
1
.
55
-
3
.
62
;
P
<
0
.
0001
)
,
pN
(
HR
,
2
.
85
;
95
%
CI
,
1
.
81
-
4
.
69
;
P
<
0
.
0001
)
,
lymphatic
invasion
(
HR
,
2
.
08
;
95
%
CI
,
1
.
26
-
3
.
70
;
P
=
0
.
0036
)
,
venous
invasion
(
HR
,
1
.
79
;
95
%
CI
,
1
.
21
-
2
.
64
;
P
=
0
.
0039
)
,
neoadjuvant
chemotherapy
(
NAC
)
(
HR
,
2
.
01
;
95
%
CI
,
1
.
35
-
3
.
00
;
P
=
0
.
0005
)
and
IMP
3
expression
(
HR
,
2
.
12
;
95
%
CI
,
1
.
40
-
3
.
29
;
P
=
0
.
0003
)
were
significantly
associated
with
overall
survival
.
Using
multivariate
analyses
,
histology
(
HR
,
1
.
87
;
95
%
CI
,
1
.
13
-
3
.
29
;
P
=
0
.
014
)
,
pN
(
HR
,
2
.
19
;
95
%
CI
,
1
.
36
-
3
.
66
;
P
=
0
.
0010
)
,
NAC
(
HR
,
1
.
88
;
95
%
CI
,
1
.
24
-
2
.
86
;
P
=
0
.
0028
)
and
IMP
3
expression
(
HR
,
1
.
84
;
95
%
CI
,
1
.
18
-
2
.
93
;
P
=
0
.
0064
)
were
significant
prognostic
factors
.
IMP
3
may
therefore
be
a
prognostic
factor
for
patients
with
ESCC
who
have
undergone
a
curative
resection
.
Diseases
Validation
Diseases presenting
"positive patients"
symptom
allergic bronchopulmonary aspergillosis
cadasil
cholangiocarcinoma
cowden syndrome
esophageal squamous cell carcinoma
heparin-induced thrombocytopenia
hodgkin lymphoma, classical
kabuki syndrome
kallmann syndrome
primary effusion lymphoma
sneddon syndrome
typhoid
waldenström macroglobulinemia
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