Esophageal squamous cell carcinoma in six harbor seals (Phoca vitulina spp.).

[esophageal squamous cell carcinoma]

Six cases of esophageal squamous cell carcinoma were identified in six captive adult Pacific (Phoca vitulina richardsii ; n = 2 ) and Atlantic (Phoca vitulina concolor ; n = 4 ) harbor seals . These seals presented with intermittent dysphagia , regurgitation , inappetence , and abnormal posturing . Common clinical pathology findings in these seals included azotemia , hyperproteinemia , hyperglobulinemia , and leukocytosis . Gastrointestinal endoscopy commonly revealed an ulcerated mass near the gastroesophageal junction . Each seal was euthanized (n = 3 ) due to poor prognosis , subsequently died while undergoing an anesthetic procedure (n = 2 ), or found dead (n = 1 ). The diagnosis of squamous cell carcinoma was confirmed via biopsy of esophageal mucosa during endoscopy or histopathologic examination of affected tissues after necropsy . On the basis of clinical and postmortem findings , esophageal squamous cell carcinoma should be considered as a differential diagnosis in aged harbor seals exhibiting clinical signs of regurgitation , decreased appetite or anorexia , vomiting , and /or abnormal posturing .

Diseases
Validation

Diseases presenting "and" symptom

achondroplasia

adrenomyeloneuropathy

aniridia

carcinoma of the gallbladder

cutaneous mastocytosis

cystinuria

esophageal squamous cell carcinoma

harlequin ichthyosis

hodgkin lymphoma, classical

hydrocephalus with stenosis of the aqueduct of sylvius

kallmann syndrome

liposarcoma

locked-in syndrome

neonatal adrenoleukodystrophy

omenn syndrome

oral submucous fibrosis

pleomorphic liposarcoma

primary hyperoxaluria type 1

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

sneddon syndrome

triple a syndrome

trochlear dysplasia

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