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Up-regulation of miR-335 predicts a favorable prognosis in esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
MicroRNAs
(
miRNAs
)
are
noncoding
RNAs
that
regulate
multiple
cellular
processes
during
cancer
progression
.
MiR-
335
has
recently
been
identified
to
be
involved
in
tumorigenesis
of
several
cancers
such
as
ovarian
cancer
and
gastric
cancer
.
However
,
the
regulation
of
miR-
335
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
has
not
been
reported
yet
.
Expression
of
miR-
335
in
tumor
and
their
normal
matched
tissues
was
determined
by
quantitative
real-time
PCR
in
67
ESCC
patients
and
its
association
with
overall
survival
of
patients
was
analyzed
by
statistical
analysis
.
The
expression
level
of
miR-
335
was
reduced
in
malignant
tissue
samples
in
comparison
to
normal
matched
tissue
(
P
<
0
.
05
)
.
It
was
also
proved
that
miR-
335
expression
was
associated
with
ESCC
histological
grade
,
lymph
node
metastasis
,
tumor
stage
and
clinical
stage
(
P
<
0
.
05
)
.
In
addition
,
the
Kaplan-
Meier
survival
curves
revealed
that
low
miR-
335
expression
was
associated
with
poor
prognosis
in
ESCC
patients
.
Multivariate
analysis
showed
that
miR-
335
expression
was
an
independent
prognostic
marker
of
overall
survival
of
ESCC
patients
.
The
study
proves
for
the
first
time
that
miR-
335
is
down
regulated
in
a
majority
of
ESCC
patients
.
Our
results
indicate
that
miR-
335
expression
is
an
independent
prognostic
factor
for
patients
with
esophageal
cancer
,
which
might
be
a
potential
valuable
biomarker
for
ESCC
.
Diseases
Validation
Diseases presenting
"first time"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
alpha-thalassemia
aniridia
aromatase deficiency
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
classical phenylketonuria
congenital adrenal hyperplasia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dentin dysplasia
dentinogenesis imperfecta
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial mediterranean fever
gm1 gangliosidosis
harlequin ichthyosis
heparin-induced thrombocytopenia
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
hydrocephalus with stenosis of the aqueduct of sylvius
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
malignant atrophic papulosis
megacystis-microcolon-intestinal hypoperistalsis syndrome
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
phenylketonuria
primary effusion lymphoma
primary hyperoxaluria type 1
severe combined immunodeficiency
sneddon syndrome
triple a syndrome
trochlear dysplasia
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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