A panel of overexpressed proteins for prognosis in esophageal squamous cell carcinoma.

[esophageal squamous cell carcinoma]

Esophageal squamous cell carcinoma (ESCC ) is a common cancer with poor prognosis . In order to identify useful biomarkers for accurately classifying prognostic risks for ESCC patients , we examined the expression of six proteins by immunohistochemistry (IHC ) in 590 paraffin-embedded ESCC samples . The candidate proteins include p 53 , EGFR , c-KIT , TIMP 1 and PI 3 K -p 110 α reported to be altered in ESCC tissues as well as another important component of PI 3 K , PI 3 K -p 85 α . Of the six proteins tested , p 53 , EGFR , c-KIT , TIMP 1 and PI 3 K -p 85 α were detected with high expression in 43 .0 %, 36 .6 %, 55 .9 %, 70 .7 % and 57 .1 % of tumors , respectively . Significant associations were found between high expression of PI 3 K -p 85 α , EGFR and p 53 and poor prognosis (P = 0 .00111 ; 0 .00001 ; 0 .00426 ). Applying these three proteins as an IHC panel could divide patients into different subgroups (P <0 .000001 ). Multivariate cox regression analysis indicated that the three -protein panel was an independent prognostic factor with very high statistical significance (HR = 2 .090 , 95 % CI : 1 .621 -2 .696 , P = 0 .00000001 ). The data suggest that the three -protein panel of PI 3 K -p 85 α , EGFR and p 53 is an important candidate biomarker for the prognosis of patients with ESCC .

Diseases
Validation

Diseases presenting "cancer" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

cadasil

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

hodgkin lymphoma, classical

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

kindler syndrome

lamellar ichthyosis

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated