Oncologic Outcomes According to Remnant Lymph Node Metastases in Pathologic T0 (ypT0) Esophageal Squamous Cell Carcinoma Following Prospective Neoadjuvant Therapy and Surgery.

[esophageal squamous cell carcinoma]

Some esophageal cancer patients may have residual nodal metastases following pathologic complete response (pCR ) of the primary tumor after neoadjuvant chemoradiotherapy (CRT ). This study examines the prognosis according to lymph node metastases in pathologic T 0 patients who received neoadjuvant CRT followed by surgery for esophageal squamous cell carcinoma (SCC ).Prospectively-collected data from patients who underwent protocol-based esophageal resection and reconstruction after neoadjuvant CRT for esophageal SCC from 2000 to 2010 at the Asan Medical Center , Seoul , Korea , were retrospectively studied . Overall survival (OS ), recurrence-free survival (RFS ), and risk factors for ypT 0 N 1 were analyzed and compared with ypT 0 N 0 .A total of 211 patients underwent prospective , protocol-based esophageal resection and reconstruction after neoadjuvant CRT for esophageal SCC . Of these , 123 patients had a pCR of the primary tumor and were enrolled in this study . Lymph node status was ypT 0 N 0 in 103 patients and ypT 0 N 1 in 20 patients . The two groups did not show significant differences in sex , initial clinical stage , tumor location , and histologic grade . Recurrence occurred in 13 patients (12 .6 %) with ypT 0 N 0 and six patients (30 .0 %) with ypT 0 N 1 , respectively (p = 0 .083 ). Five -year OS and RFS of ypT 0 N 1 were 42 .8 ± 13 .9 and 41 .7 ± 12 .8 %, respectively . Survival was compared between the two groups using a log-rank test , and there were no significant differences for OS or RFS .Residual lymph node metastases did not significantly influence prognosis in pathologic T 0 patients who received neoadjuvant CRT followed by surgery for esophageal SCC .

Diseases
Validation

Diseases presenting "cancer" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

cadasil

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

hodgkin lymphoma, classical

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

kindler syndrome

lamellar ichthyosis

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated