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A disintegrin and metalloproteinase 17 mRNA and protein expression in esophageal squamous cell carcinoma, as well as its clinicopathological factors and prognosis.
[esophageal squamous cell carcinoma]
The
aim
of
the
present
study
was
to
explore
a
disintegrin
and
metalloproteinase
Â
17
(
ADAM
17
)
mRNA
and
protein
expression
in
esophageal
squamous
cell
carcinoma
and
its
association
with
clinicopathological
factors
and
prognosis
.
Through
semi‑quantitative
reverse
transcription
polymerase
chain
reaction
,
the
ADAM
17
mRNA
expression
in
50
Â
cases
of
esophageal
squamous
cell
carcinoma
and
corresponding
normal
esophageal
mucosa
were
detected
.
Using
streptavidin
peroxidase
conjugated
immunohistochemistry
,
ADAM
17
protein
levels
were
detected
in
80
cases
of
esophageal
squamous
cell
carcinoma
and
corresponding
normal
esophageal
mucosa
.
A
log
rank
test
and
the
Cox
proportional
hazards
model
were
used
for
the
esophageal
cancer
survival
analysis
.
ADAM
17
mRNA
expression
levels
in
esophageal
squamous
cell
carcinoma
and
corresponding
normal
esophageal
mucosa
were
0
.
937
±
0
.
241
and
0
.
225
±
0
.
077
,
respectively
Â
(
P
<
0
.
01
)
.
ADAM
17
mRNA
expression
in
esophageal
squamous
cell
carcinoma
was
correlated
with
lymph
node
metastasis
(
P
<
0
.
01
)
and
tumor
,
node
and
metastasis
(
TNM
)
staging
(
P
<
0
.
05
)
,
however
,
it
was
not
correlated
with
gender
,
age
or
histological
grade
(
P
>
0
.
05
)
.
ADAM
17
protein
expression
rates
in
esophageal
squamous
cell
carcinoma
and
corresponding
normal
esophageal
mucosa
were
66
.
25
and
6
.
25
%
respectively
,
a
difference
that
was
statistically
significant
(
P
<
0
.
01
)
.
In
addition
,
ADAM
17
protein
expression
in
esophageal
squamous
cells
was
correlated
with
lymph
node
metastasis
and
TNM
stage
(
P
<
0
.
05
)
,
while
it
was
not
correlated
with
gender
,
age
or
histological
grade
(
P
>
0
.
05
)
.
ADAM
17
protein
expression
and
epidermal
growth
factor
receptor
(
EGFR
)
protein
expression
were
positively
correlated
(
P
<
0
.
01
)
.
Lymph
node
metastasis
,
TNM
stage
,
ADAM
17
and
EGFR
protein
expression
may
be
used
as
independent
prognostic
indicators
of
esophageal
squamous
cell
carcinoma
(
all
P
<
0
.
05
)
.
ADAM
17
mRNA
and
protein
were
highly
expressed
in
esophageal
squamous
cell
carcinoma
;
they
have
important
roles
in
invasion
and
metastasis
and
a
certain
value
in
judging
the
prognosis
of
patients
with
esophageal
squamous
cell
carcinoma
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated