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Notch Signaling Target Genes are Directly Correlated to Esophageal Squamous Cell Carcinoma Tumorigenesis.
[esophageal squamous cell carcinoma]
Notch
signaling
is
an
important
cellular
pathway
which
affects
the
development
and
function
of
many
organs
.
It
plays
critical
roles
in
maintaining
of
progenitor
stem
cell
population
as
well
as
balancing
cell
proliferation
,
survival
,
differentiation
and
apoptosis
.
It
has
been
shown
that
notch
signaling
is
aberrantly
activated
during
the
carcinogenesis
of
a
variety
of
human
cancers
.
In
this
study
we
aimed
to
explore
activation
of
this
signaling
pathway
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
through
expressional
analysis
of
notch
signaling
target
genes
.
The
mRNA
expression
of
HEY
1
and
HEY
2
was
comparatively
analyzed
by
real-time
PCR
in
tumor
and
related
margin
normal
tissues
of
50
ESCC
patients
.
Comparative
quantitative
real-time
PCR
indicates
the
overexpression
of
HEY
1
and
HEY
2
in
54
and
30
Â
%
of
ESCC
samples
,
respectively
.
Overexpression
of
HEY
1
was
significantly
associated
with
stage
of
the
tumor
(
p
 
=
 
0
.
048
)
and
tumor
location
(
p
 
=
 
0
.
008
)
.
HEY
2
overexpression
was
also
significantly
correlated
to
node
metastasis
of
tumor
cells
(
p
 
=
 
0
.
043
)
.
Overexpression
of
HEY
1
and
HEY
2
in
ESCC
is
correlated
to
different
indices
of
poor
prognosis
and
it
is
extrapolated
that
such
overexpression
is
important
in
progression
and
development
of
ESCC
tumorigenesis
.
To
the
best
of
our
knowledge
,
this
is
the
first
report
introducing
aberrant
activation
of
notch
signaling
target
genes
in
ESCC
,
where
it
plays
roles
in
development
and
progression
of
the
malignancy
and
may
be
considered
in
therapeutic
modalities
to
restrict
ESCC
progression
.
Diseases
Validation
Diseases presenting
"poor prognosis"
symptom
adrenal incidentaloma
alexander disease
alpha-thalassemia
carcinoma of the gallbladder
cholangiocarcinoma
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
malignant atrophic papulosis
megacystis-microcolon-intestinal hypoperistalsis syndrome
papillon-lefèvre syndrome
pleomorphic liposarcoma
primary effusion lymphoma
pyomyositis
sneddon syndrome
systemic capillary leak syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
zellweger syndrome
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