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Notch Signaling Target Genes are Directly Correlated to Esophageal Squamous Cell Carcinoma Tumorigenesis.
[esophageal squamous cell carcinoma]
Notch
signaling
is
an
important
cellular
pathway
which
affects
the
development
and
function
of
many
organs
.
It
plays
critical
roles
in
maintaining
of
progenitor
stem
cell
population
as
well
as
balancing
cell
proliferation
,
survival
,
differentiation
and
apoptosis
.
It
has
been
shown
that
notch
signaling
is
aberrantly
activated
during
the
carcinogenesis
of
a
variety
of
human
cancers
.
In
this
study
we
aimed
to
explore
activation
of
this
signaling
pathway
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
through
expressional
analysis
of
notch
signaling
target
genes
.
The
mRNA
expression
of
HEY
1
and
HEY
2
was
comparatively
analyzed
by
real-time
PCR
in
tumor
and
related
margin
normal
tissues
of
50
ESCC
patients
.
Comparative
quantitative
real-time
PCR
indicates
the
overexpression
of
HEY
1
and
HEY
2
in
54
and
30
Â
%
of
ESCC
samples
,
respectively
.
Overexpression
of
HEY
1
was
significantly
associated
with
stage
of
the
tumor
(
p
 
=
 
0
.
048
)
and
tumor
location
(
p
 
=
 
0
.
008
)
.
HEY
2
overexpression
was
also
significantly
correlated
to
node
metastasis
of
tumor
cells
(
p
 
=
 
0
.
043
)
.
Overexpression
of
HEY
1
and
HEY
2
in
ESCC
is
correlated
to
different
indices
of
poor
prognosis
and
it
is
extrapolated
that
such
overexpression
is
important
in
progression
and
development
of
ESCC
tumorigenesis
.
To
the
best
of
our
knowledge
,
this
is
the
first
report
introducing
aberrant
activation
of
notch
signaling
target
genes
in
ESCC
,
where
it
plays
roles
in
development
and
progression
of
the
malignancy
and
may
be
considered
in
therapeutic
modalities
to
restrict
ESCC
progression
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated
