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Silencing of insulin-like growth factor-1 receptor enhances the radiation sensitivity of human esophageal squamous cell carcinoma in vitro and in vivo.
[esophageal squamous cell carcinoma]
Esophageal
squamous
cell
carcinoma
(
ESCC
)
is
a
prevalent
fatal
cancer
worldwide
,
and
the
number
of
deaths
due
to
this
disease
is
increasing
.
Due
to
ESCC
resistance
to
chemotherapy
and
radiation
treatment
,
new
therapies
are
urgently
needed
for
the
improvement
of
ESCC
patient
clinical
outcomes
.
Eca-
109
and
TE-
1
cells
were
transfected
with
100
nM
IGF-
1
r
siRNA
,
and
a
combination
of
IGF-
1
r
siRNA
and
radiation
therapy
was
tested
in
vitro
and
in
vivo
.
The
effects
of
IGF-
1
r
siRNA
were
determined
through
Western
blotting
and
flow
cytometry
experiments
.
After
radiotherapy
,
the
number
of
IGF-
1
r
siRNA-transfected
Eca-
109
cells
decreased
by
approximately
67
.
3
%
,
and
a
78
.
9
%
reduction
was
observed
in
the
transfected
TE-
1
cells
.
In
addition
,
the
Eca-
109
and
TE-
1
cells
that
were
irradiated
following
IGF-
1
r
knockdown
contained
16
.
2
%
and
20
.
3
%
apoptotic
cells
,
respectively
.
The
results
of
the
current
study
suggest
that
IGF-
1
r
knockdown
may
enhance
the
radiation
sensitivity
of
ESCC
and
increase
the
therapeutic
effects
of
radiation
both
in
vitro
and
in
vivo
.
These
results
provide
strong
evidence
that
the
targeted
application
of
siRNA
will
enable
the
development
of
new
therapeutic
strategies
for
the
clinical
treatment
of
ESCC
patients
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
