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Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
Esophageal
squamous
cell
carcinoma
(
ESCC
)
is
one
of
the
prevalent
and
deadly
cancers
worldwide
,
especially
in
Eastern
Asia
.
The
prognosis
of
ESCC
remains
poor
;
thus
,
it
is
still
necessary
to
further
dissect
the
underlying
mechanisms
and
explore
therapeutic
targets
of
ESCC
.
Recent
studies
show
that
long
noncoding
RNAs
(
lncRNAs
)
have
critical
roles
in
diverse
biological
processes
,
including
tumorigenesis
.
Some
lncRNAs
,
such
as
HOTAIR
and
POU
3
F
3
,
were
reported
to
play
important
roles
in
ESCC
.
Here
,
we
characterized
the
expression
profile
of
taurine-upregulated
gene
1
(
TUG
1
)
,
a
lncRNA
recruiting
and
binding
to
polycomb
repressive
complex
2
(
PRC
2
)
,
in
ESCC
.
In
a
cohort
of
62
patients
,
TUG
1
was
significantly
overexpressed
in
ESCC
tissues
compared
with
paired
adjacent
normal
tissues
,
and
high
expression
level
of
TUG
1
was
associated
with
family
history
and
upper
segment
of
esophageal
cancer
(
p
 
<
 
0
.
05
)
.
Further
,
in
vitro
silencing
TUG
1
via
siRNA
inhibited
the
proliferation
and
migration
of
ESCC
cells
and
blocked
the
progression
of
cell
cycle
.
Therefore
,
our
study
indicates
that
TUG
1
promotes
proliferation
and
migration
of
ESCC
cells
and
is
a
potential
oncogene
of
ESCC
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated
