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Long-term outcome after endoscopic submucosal dissection in patients with superficial esophageal squamous cell carcinoma: a single-center study.
[esophageal squamous cell carcinoma]
Superficial
esophageal
squamous
cell
carcinoma
(
SESCC
)
is
being
increasingly
detected
during
screening
endoscopy
.
Endoscopic
submucosal
dissection
(
ESD
)
allows
for
en
bloc
and
histologically
complete
resection
of
lesions
.
This
study
assessed
the
technical
feasibility
and
long
-term
outcomes
of
ESD
for
SESCCs
.
Between
January
2005
and
August
2012
,
27
patients
with
28
SESCCs
underwent
ESD
at
Pusan
National
University
Hospital
.
The
en
bloc
and
pathologically
complete
resection
rates
,
complication
(
perforation
and
bleeding
)
rate
,
incidence
of
esophageal
stricture
after
ESD
,
and
overall
and
disease-
specific
survival
rates
were
evaluated
.
The
en
bloc
and
pathologically
complete
resection
rates
were
93
%
and
83
%
,
respectively
.
No
significant
bleeding
occurred
,
and
perforation
with
mediastinal
emphysema
was
observed
in
two
patients
(
7
%
)
.
Post-
ESD
stricture
occurred
in
two
patients
(
7
%
)
who
had
mucosal
defects
involving
more
than
three
-fourths
of
the
esophageal
circumference
.
During
a
mean
follow-up
of
23
months
,
local
tumor
recurrence
was
seen
in
two
of
four
lesions
with
pathologically
incomplete
resection
;
one
was
treated
by
re
-
ESD
,
and
the
other
was
treated
by
surgical
esophagectomy
.
The
5
-
year
overall
and
disease-
specific
survival
rates
were
84
%
and
100
%
,
respectively
.
ESD
seems
to
be
a
feasible
,
effective
curative
treatment
for
SESCCs
.
All
patients
should
be
closely
followed
after
ESD
.
Diseases
Validation
Diseases presenting
"long-term outcomes"
symptom
acute rheumatic fever
alpha-thalassemia
aromatase deficiency
cholangiocarcinoma
classical phenylketonuria
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cushing syndrome
dystrophic epidermolysis bullosa
esophageal squamous cell carcinoma
hirschsprung disease
homocystinuria without methylmalonic aciduria
kabuki syndrome
lamellar ichthyosis
omenn syndrome
phenylketonuria
proteus syndrome
trochlear dysplasia
von hippel-lindau disease
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