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MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
MicroRNAs
(
miRNAs
)
play
a
critical
role
in
development
and
progression
of
cancers
.
Deregulation
of
MicroRNA-
9
(
miR-
9
)
has
been
documented
in
many
types
of
cancers
but
their
role
in
the
development
of
esophageal
squamous
cell
carcinoma
(
ESCC
)
has
not
been
studied
.
This
study
aimed
to
investigate
the
effect
of
miR-
9
in
esophageal
cancer
metastasis
.
The
up-regulation
of
miR-
9
was
frequently
detected
in
primary
ESCC
tumor
tissue
,
which
was
significantly
associated
with
clinical
progression
(
P
=
0
.
022
)
,
lymph
node
metastasis
(
P
=
0
.
007
)
and
poor
overall
survival
(
P
<
0
.
001
)
.
Functional
study
demonstrated
that
miR-
9
promoted
cell
migration
and
tumor
metastasis
,
which
were
effectively
inhibited
when
expression
of
miR-
9
was
silenced
.
Moreover
,
we
demonstrated
that
miR-
9
interacted
with
the
3
'
-
untranslated
region
of
E
-
cadherin
and
down-regulated
its
expression
,
which
induced
β-catenin
nuclear
translocation
and
subsequently
up-regulated
c-myc
and
CD
44
expression
.
In
addition
,
miR-
9
induced
epithelial-mesenchymal
transition
(
EMT
)
in
ESCC
,
a
key
event
in
tumor
metastasis
.
Taken
together
,
our
study
demonstrates
that
miR-
9
plays
an
important
role
in
ESCC
metastasis
by
activating
β-catenin
pathway
and
inducing
EMT
via
targeting
E
-
cadherin
.
Our
study
also
suggests
miR-
9
can
be
served
as
a
new
independent
prognostic
marker
and
/
or
as
a
novel
potential
therapeutic
target
for
ESCC
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated