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Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
To
investigate
the
clinical
prognostic
value
of
protein
tyrosine
kinase
6
(
PTK
6
)
in
patients
with
esophageal
squamous
cell
carcinoma
(
ESCC
)
,
quantitative
RT-PCR
and
Western
blotting
were
utilized
to
measure
the
mRNA
and
protein
expression
levels
of
PTK
6
in
29
and
eight
pairs
of
ESCC
and
peritumoral
normal
esophageal
tissues
,
respectively
.
Furthermore
,
the
expression
of
PTK
6
protein
in
210
ESCCs
was
examined
with
immunohistochemistry
(
IHC
)
,
and
its
clinical
value
was
analyzed
using
Kaplan-
Meier
plots
and
the
Cox
proportional
hazards
regression
model
.
The
results
found
that
the
expression
levels
of
both
PTK
6
mRNA
and
protein
in
ESCC
tissues
were
significantly
lower
than
those
in
peritumoral
normal
esophageal
tissues
.
Regarding
the
IHC
analysis
of
ESCC
,
the
cytoplasmic
expression
of
PTK
6
was
significantly
correlated
with
tumor
grade
(
P
Â
<
Â
0
.
001
)
.
Compared
with
patients
with
low
PTK
6
expression
,
ESCC
patients
with
overexpression
of
PTK
6
displayed
preferable
disease-free
survival
(
DFS
)
and
overall
survival
(
OS
)
(
P
Â
<
Â
0
.
001
and
P
Â
=
Â
0
.
001
,
respectively
)
,
especially
in
stage
II
disease
(
P
Â
=
Â
0
.
002
and
P
Â
=
Â
0
.
021
,
respectively
)
.
PTK
6
was
evaluated
as
an
independent
prognostic
factor
for
ESCC
using
multivariate
Cox
regression
analysis
.
All
data
demonstrated
that
the
expression
level
of
PTK
6
is
an
independent
prognostic
factor
in
ESCCs
.
Low
expression
of
PTK
6
is
correlated
with
poor
DFS
and
OS
in
ESCCs
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated
