The combination of platelet count and neutrophil lymphocyte ratio is a predictive factor in patients with esophageal squamous cell carcinoma.

[esophageal squamous cell carcinoma]

The prognostic value of inflammation indexes in esophageal cancer was not established . In this study , therefore , both prognostic values of Glasgow prognostic score (GPS ) and combination of platelet count and neutrophil lymphocyte ratio (COP-NLR ) in patients with esophageal squamous cell carcinoma (ESCC ) were investigated and compared .This retrospective study included 375 patients who underwent esophagectomy for ESCC . The cancer -specific survival (CSS ) was calculated by the Kaplan-Meier method , and the difference was assessed by the log-rank test . The GPS was calculated as follows : patients with elevated C-reactive protein (> 10 mg /l ) and hypoalbuminemia (< 35 g /l ) were assigned to GPS 2 . Patients with one or no abnormal value were assigned to GPS 1 or GPS 0 , respectively . The COP-NLR was calculated as follows : patients with elevated platelet count (> 300 × 10 (9 )/l ) and neutrophil lymphocyte ratio (> 3 ) were assigned to COP-NLR 2 . Patients with one or no abnormal value were assigned to COP-NLR 1 or COP-NLR 0 , respectively .The 5 -year CSS in patients with GPS 0 , 1 , and 2 was 50 .0 %, 27 .0 %, and 12 .5 %, respectively (P < .001 ). The 5 -year CSS in patients with COP-NLR 0 , 1 , and 2 was 51 .8 %, 27 .0 %, and 11 .6 %, respectively (P < .001 ). Multivariate analysis showed that both GPS (P = .003 ) and COP-NLR (P = .003 ) were significant predictors in such patients . In addition , our study demonstrated a similar hazard ratio (HR ) between COP-NLR and GPS (HR = 1 .394 vs HR = 1 .367 ).COP-NLR is an independent predictive factor in patients with ESCC . We conclude that COP-NLR predicts survival in ESCC similar to GPS .

Diseases
Validation

Diseases presenting "cancer" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

cadasil

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

hodgkin lymphoma, classical

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

kindler syndrome

lamellar ichthyosis

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated